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Case Reports
. 2016 Jul-Sep;7(3):142-5.
doi: 10.4103/0976-500X.189681.

Oxcarbazepine-induced drug rash with eosinophilia and systemic symptoms syndrome presenting as exfoliative dermatitis

Mahimanjan Saha  1 , Surajit Gorai  2 , Vaswatee Madhab  1
Affiliations
Case Reports

Oxcarbazepine-induced drug rash with eosinophilia and systemic symptoms syndrome presenting as exfoliative dermatitis

Mahimanjan Saha et al. J Pharmacol Pharmacother. 2016 Jul-Sep.

Abstract

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a type of severe adverse cutaneous drug reaction characterized by fever, skin eruption, hematological abnormalities, and internal organ involvement. Although anticonvulsant drugs are mainly implicated in DRESS, newer anticonvulsants such as oxcarbazepine-induced definite cases of DRESS syndrome are rare and oxcarbazepine-induced DRESS syndrome presenting as exfoliative dermatitis is even rarer. We report a case of a 35-year-old male who developed DRESS syndrome presenting as exfoliative dermatitis after taking oxcarbazepine for 3 weeks.

Keywords: Drug rash with eosinophilia and systemic symptoms; exfoliative dermatitis; oxcarbazepine.

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Figures

Figure 1
Figure 1
Diffuse facial edema with scaling and erythema over the face and upper trunk
Figure 2
Figure 2
Brown-to-black semi-adherent scaling with underlying erythema involving most of the body parts
Figure 3
Figure 3
Structure of oxcarbazepine
See this image and copyright information in PMC

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