Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Aug;5(4):482-6.
doi: 10.21037/tau.2016.06.10.

The drug treatment of premature ejaculation

Shin-Ichi Hisasue  1
Affiliations
Review

The drug treatment of premature ejaculation

Shin-Ichi Hisasue. Transl Androl Urol. 2016 Aug.

Abstract

The management recommendation for both acquired premature ejaculation (APE) and lifelong PE (LPE) are similar, such as a behavioral/psychotherapy, a pharmacotherapy and a combination of these treatments. For the drug treatment for PE, gold standard is selective serotonin reuptake inhibitors (SSRIs) including dapoxetine or paroxetine. The drug treatment for PE is still developing and some new promising therapeutic options have been proposed. Topical anesthetics, tramadol, and alpha-1 blockers will be the next strategies of the drug treatment for PE in the future.

Keywords: Premature ejaculation (PE); alpha-1 blocker; drug; selective serotonin reuptake inhibitors (SSRIs).

PubMed Disclaimer

Conflict of interest statement

The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
IELT with on-demand dosing of dapoxetine (18). IELT, intravaginal ejaculatory latency time.
Figure 2
Figure 2
The combination of dapoxetine and behavioral treatment provides better results than dapoxetine alone (24). IELT, intravaginal ejaculatory latency time; SSRI, selective serotonin reuptake inhibitor.
Figure 3
Figure 3
The efficacy of silodosin on acquired PE (48). PE, premature ejaculation; IELT, intravaginal ejaculatory latency time.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Althof SE, Abdo CH, Dean J, et al. International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation. J Sex Med 2010;7:2947-69. 10.1111/j.1743-6109.2010.01975.x - DOI - PubMed
    1. McMahon CG, Touma K. Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J Urol 1999;161:1826-30. 10.1016/S0022-5347(05)68816-7 - DOI - PubMed
    1. McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study. J Urol 1998;159:1935-8. 10.1016/S0022-5347(01)63201-4 - DOI - PubMed
    1. Atmaca M, Kuloglu M, Tezcan E, et al. The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study. Int J Impot Res 2002;14:502-5. 10.1038/sj.ijir.3900918 - DOI - PubMed
    1. Kara H, Aydin S, Yücel M, et al. The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study. J Urol 1996;156:1631-2. 10.1016/S0022-5347(01)65467-3 - DOI - PubMed