Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Aug;6(Suppl 2):S153-9.
doi: 10.4103/2231-0762.189753.

Efficacy of platelet rich fibrin in the treatment of human intrabony defects with or without bone graft: A randomized controlled trial

Nikhil D Chandradas  1 , Shivamurthy Ravindra  2 , Vivekananda M Rangaraju  2 , Sheetal Jain  3 , Shivaprasad Dasappa  2
Affiliations

Efficacy of platelet rich fibrin in the treatment of human intrabony defects with or without bone graft: A randomized controlled trial

Nikhil D Chandradas et al. J Int Soc Prev Community Dent. 2016 Aug.

Abstract

Aim: To evaluate the efficacy of platelet rich fibrin (PRF) with or without bone graft [demineralized bone matrix (DBM) graft] in the treatment of intrabony defects based on clinical and radiographic parameters.

Materials and methods: Thirty six intrabony defects in 36 patients were randomly divided into three different groups and were treated with group A (PRF with DBM) or group B (PRF alone) or group C [open flap debridement (OFD)]. Clinical parameters such as plaque index (PI), gingival index (GI), probing depth (PD), relative attachment level (RAL), and gingival recession (GR) were assessed at baseline and 9 months postoperatively; radiographic parameters such as linear bone growth (LBG) and percentage in bone fill (%BF) were calculated by using the image analysis software. Comparisons of groups were analyzed using Kruskal-Wallis analysis of variance test. Pair-wise comparison of groups was done by Mann-Whitney U test.

Results: Mean PD reduction and RAL gain were greater in group A (4.25 ± 1.48, 3.92 ± 0.90) and group B (3.82 ± 0.75, 3.27 ± 0.65) than control (3.00 ± 1.21, 2.25 ± 0.62). Furthermore, statistically significant improvement in LBG and %BF was found in group A (3.47 ± 0.53, 61.53 ± 4.54) compared to group B (2.55 ± 0.61, 49.60 ± 14.08) and group C (1.21 ± 0.80, 24.69 ± 15.59).

Conclusions: The study demonstrated that PRF improves clinical and radiological parameters compared to OFD alone in intrabony defects. Addition of DBM enhances the effects of PRF in RAL gain and radiographic defect fill.

Keywords: Chronic periodontitis; clinical trial; periodontal attachment loss; platelet-derived growth factor; regeneration.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Consolidated standard of reporting trials (CONSORT) flow chart. N: Number of patients, PRF: Platelet. rich fibrin, DBM: Demineralized bone matrix xenograft
Figure 2
Figure 2
Radiographic appearance at baseline for site treated with PRF + DBM. AUX 1: Auxillary line 1 was drawn in the direction of tooth long axis, A: Cementoenamel junction (CEJ), C: Most coronal extension of the lateral wall of intrabony defect, AUX 2: Auxillary line 2 was drawn perpendicular to the tooth long axis and through point C, D: Base of the defect, B: Point where AUX 2 cross the contour of the root to point
Figure 3
Figure 3
Radiographic appearance at 9 months for site treated with PRF + DBM. AUX 1: Auxillary line 1 was drawn in the direction of tooth long axis, A: Cementoenamel junction (CEJ), C: Most coronal extension of the lateral wall of intrabony defect, AUX 2: Auxillary line 2 was drawn perpendicular to the tooth long axis and through point C, D: Base of the defect, B: Point where AUX 2 cross the contour of the root to point D
See this image and copyright information in PMC

References

    1. Reynolds MA, Kao RT, Camargo PM, Caton JG, Clem DS, Fiorellini JP, et al. Periodontal regeneration – Intrabony defects: A consensus report from the AAP Regeneration Workshop. J Periodontol. 2015;86:S105–7. - PubMed
    1. Wang ZS, Feng ZH, Wu GF, Bai SZ, Dong Y, Chen FM, et al. The use of platelet-rich fibrin combined with periodontal ligament and jaw bone mesenchymal stem cell sheets for periodontal tissue engineering. Sci Rep. 2016;6:28126. - PMC - PubMed
    1. Kim TH, Kim SH, Sandor GK, Kim YD. Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing. Arch Oral Biol. 2014;59:550–8. - PubMed
    1. Choukroun J, Adda F, Schoeffler C, Vervelle A. PRF: An opportunity in perio-implantology. Implantodontie. 2001;42:55–62.
    1. Dohan DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukrouns platelet-rich fibrin (PRF): A gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. 2009;27:63–9. - PubMed