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. 2016 May 19;3(4):e1164279.
doi: 10.1080/23723556.2016.1164279. eCollection 2016 Jul.

Asymmetric division: An antitumor player?

Lihua Wang  1 , Pengcheng Bu  2 , Xiling Shen  3
Affiliations

Asymmetric division: An antitumor player?

Lihua Wang et al. Mol Cell Oncol. .

Abstract

miR-34a-mediated asymmetric cell division reins in excessive stem cell expansion during tissue regeneration in the intestine and colon. Loss of miR-34a switches asymmetric division to symmetric division and enhances stem cell proliferation. Asymmetric division also occurs in the early stages of colon cancer stem cells. Mechanistically, miR-34a, Numb, and Notch form a feed-forward loop that specifies cell fate when stem cells divide.

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Figures

Figure 1.
Figure 1.
miR-34a-mediated asymmetric divisions in stem cells. Asymmetric division mechanisms are silenced in normal intestine or colon stem cells. The asymmetric division rate increases to rein in excessive stem cell expansion during tissue regeneration caused by inflammation. Loss of miR-34a enhances symmetric division and stem cell proliferation.
See this image and copyright information in PMC

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