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Review
. 2016 Dec;23(6):423-429.
doi: 10.1097/MED.0000000000000294.

FGF-23 and cardiovascular disease: review of literature

Jasveen Batra  1 , Rupinder Singh Buttar, Pardeep Kaur, Jacqueline Kreimerman, Michal L Melamed
Affiliations
Review

FGF-23 and cardiovascular disease: review of literature

Jasveen Batra et al. Curr Opin Endocrinol Diabetes Obes. 2016 Dec.

Abstract

Purpose of review: This review examines associations between fibroblast growth factor 23 (FGF-23) and cardiovascular disease.

Recent findings: FGF-23 is a hormone produced by osteocytes and osteoblasts that aids with phosphate excretion by the kidney and acts as a negative feedback regulator for activated vitamin D synthesis. Recent studies have found associations between elevated FGF-23 levels and a number of cardiovascular diseases, including hypertension, left ventricular hypertrophy, endothelial dysfunction, cardiovascular events and mortality.

Conclusion: Recent studies have explored the possible effects of FGF-23 on the cardiovascular system. In animal and observational human studies, there is a link between elevated FGF-23 levels and multiple cardiovascular outcomes, including hypertension, left ventricular hypertrophy and cardiovascular events and mortality. Further studies are required to evaluate whether decreasing FGF-23 levels improves cardiovascular outcomes.

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Conflict of interest statement

CONFLICTS OF INTEREST

None of the authors report any conflicts of interest.

Figures

Fig 1
Fig 1
Highlights of the associations described in the review. Phosphate, PTH and 1,25-dihydroxyvitamin D lead to increased FGF-23 levels. Elevated FGF-23 levels may lead to hypertension through effects in the kidney and cardiovascular diseases and mortality.
See this image and copyright information in PMC

References

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