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. 2016 Sep;111(9):594-6.
doi: 10.1590/0074-02760160227.

Genome-wide analyses of HTLV-1aD strains from Cape Verde, Africa

Louise Zanella  1 , Isabel de Pina-Araujo I  2 , Mariza G Morgado  3 , Ana Carolina Vicente  1
Affiliations

Genome-wide analyses of HTLV-1aD strains from Cape Verde, Africa

Louise Zanella et al. Mem Inst Oswaldo Cruz. 2016 Sep.

Abstract

We characterised and reported the first full-length genomes of Human T-cell Lymphotropic Virus Type 1 subgroup HTLV-1aD (CV21 and CV79). This subgroup is one of the major determinants of HTLV-1 infections in North and West Africa, and recombinant strains involving this subgroup have been recently demonstrated. The CV21 and CV79 strains from Cape Verde/Africa were characterised as pure HTLV-1aD genomes, comparative analyses including HTLV-1 subtypes and subgroups revealed HTLV-1aD signatures in the envelope, pol, and pX regions. These genomes provide original information that will contribute to further studies on HTLV-1a epidemiology and evolution.

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Figures

Fig. 1
Fig. 1. : genome maps and features of HTLV-1aD subgroup considering only LTR5´. The inner circle represents the HTLV-1aD genome following by percent of GC content and the other circles represents the genome annotation.
Fig. 2
Fig. 2. : Maximum Likelihood tree based on HTLV-1 entire genome sequences. Sequences derived from this study are in red. Numbers besides internal branches indicate bootstrap values based on 1000 replicates.
See this image and copyright information in PMC

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