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Comment
. 2016 Sep 20;45(3):459-461.
doi: 10.1016/j.immuni.2016.08.020.

Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity

Gangqing Hu  1 , Keji Zhao  2
Affiliations
Comment

Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity

Gangqing Hu et al. Immunity. .

Abstract

We are beginning to understand the function of 3D genome architecture in the immune system. In this issue, Bunting et al. (2016) reported massive multi-layer genome reorganization from naive B cells to germinal center B cells, centered on a locus control region of Bcl6.

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Figures

Figure 1.
Figure 1.. Multi-layer 3D Chromatin Reorganization during the Transition from Naive B Cells to GC B Cells
Top: loss of interactions between p- and q-arms of a chromosome. Middle: merge of gene neighborhoods into gene “cities” with enhanced interactions among promotors and enhancers. Bottom: reorganization of 3D chromatin interactions centered on Bcl6 and an upstream LCR, accompanied by upregulation of GC-specific (GC-sp) transcription program.
See this image and copyright information in PMC

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References

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