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Comment
. 2016 Sep 20;45(3):464-466.
doi: 10.1016/j.immuni.2016.09.002.

HSC Contribution in Making Steady-State Blood

Keisuke Ito  1 , Paul S Frenette  2
Affiliations
Comment

HSC Contribution in Making Steady-State Blood

Keisuke Ito et al. Immunity. .

Abstract

In homeostasis, whether blood cells are derived from committed progenitor or mutipotent stem cell activity remains controversial. In this issue of Immunity, Sawai et al. (2016) describe murine HSCs as the major contributor to the maintenance of multilineage hematopoiesis, both in the steady state and during cytokine response.

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Figures

Figure 1
Figure 1. HSCs Provide Major Contribution of Steady-State Hematopoiesis
HSCs to MPP (dashed line) might be the rate-limiting transition. This transition is followed by rapid and massive amplification at progenitor stages for continuous production of large numbers of mature cells (left). Pdzk1ip1-CreER transgene efficiently marks self-renewing HSC cells, and its labeling is rapidly accumulated in most of committed progenitors and mature cells during unperturbed hematopoiesis. MPP, multi-potent progenitor.
See this image and copyright information in PMC

Comment on

References

    1. Acar M, Kocherlakota KS, Murphy MM, Peyer JG, Oguro H, Inra CN, Jaiyeola C, Zhao Z, Luby-Phelps K, Morrison SJ. Nature. 2015;526:126–130. - PMC - PubMed
    1. Barber CL, Montecino-Rodriguez E, Dorsh-kind K. Proc. Natl. Acad. Sci. USA. 2011;108:13700–13704. - PMC - PubMed
    1. Biasco L, Pellin D, Scala S, Dionisio F, Basso-Ricci L, Leonardelli L, Scaramuzza S, Baricordi C, Ferrua F, Cicalese MP, et al. Cell Stem Cell. 2016;19:107–119. - PMC - PubMed
    1. Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz T, Schlenner SM, Reth M, Höfer T, Rodewald HR. Nature. 2015;518:542–546. - PubMed
    1. Dykstra B, Kent D, Bowie M, McCaffrey L, Hamilton M, Lyons K, Lee SJ, Brinkman R, Eaves C. Cell Stem Cell. 2007;1:218–229. - PubMed