[Prevention and treatment of energy failure in neonates with hypoxic-ischemic encephalopathy]

Abstract

Hypoxic-ischemic encephalopathy (HIE) in neonates is the brain injury caused by perinatal asphyxia or hypoxia and is a major cause of death in neonates and nervous system dysfunction in infants and young children. Although to a certain degree, mild hypothermia therapy reduces the mortality of infants with moderate to severe HIE, it cannot achieve the expected improvements in nervous system dysfunction. Hence, it is of vital importance to search for effective therapeutic methods for HIE. The search for more therapies and better preventive measures based on the pathogenesis of HIE has resulted in much research. As an important link in the course of HIE, energy failure greatly affects the development and progression of HIE. This article reviews the research advances in the treatment and prevention of energy failure in the course of HIE.

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ATP与ADP的转换当代谢活跃时，ATP在ATP酶的作用下水解为ADP和游离磷酸基团，释放能量为机体供能；当能量需求相对较小时，ATP则在CK的作用下将高能磷酸键转移至Cr，生成PCr，CK催化的这一反应为可逆反应，当机体需要能量时，ADP和PCr可在CK作用下迅速生成ATP供能。[CK]肌酸激酶；[Cr]肌酸；[PCr]磷酸肌酸。