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. 2016 Nov 15;7(46):75094-75103.
doi: 10.18632/oncotarget.12058.

The clinicopathologic relevance and prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy

Xiao-Li Wei  1 , Miao-Zhen Qiu  1   2 , Yi-Xin Zhou  1 , Ming-Ming He  1 , Hui-Yan Luo  1 , Feng-Hua Wang  1 , Dong-Sheng Zhang  1 , Yu-Hong Li  1 , Rui-Hua Xu  1
Affiliations

The clinicopathologic relevance and prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy

Xiao-Li Wei et al. Oncotarget. .

Abstract

The clinicopathologic relevance and prognostic value of tumor deposits in colorectal cancer has been widely demonstrated. However, there are still debates in the prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy. In this study, rectal cancer with preoperative radiotherapy followed by resection of primary tumors registered in Surveillance, Epidemiology and End Results (SEER) database from 2010-2012 were analyzed. There were 4,813 cases eligible for this study, and tumor deposits were found in 514 (10.7%) cases. The presence of tumor deposits was significantly associated with some aggressive characteristics, including poorer tumor differentiation, more advanced ypT category, ypN category and ypTNM stage, distant metastasis, elevated carcinoembryonic antigen, higher positive rates of circumferential resection margin and perineural invasion (all P < = 0.001). Tumor deposit was also an independent negative prognostic factor for cancer-specific survival in rectal cancer with preoperative radiotherapy (adjusted HR and 95% CI: 2.25 (1.51 - 3.35)). N1c category had significant worse survival compared with N0 category (adjusted HR and 95% CI: 2.41 (1.24 - 4.69)). In conclusion, tumor deposit was a significant and independent prognostic factor, and the N1c category by the 7th edition of AJCC/TNM staging system was applicable in rectal cancer with preoperative radiotherapy.

Keywords: SEER; preoperative radiotherapy; prognosis; rectal cancer; tumor deposits.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare no conflicts of interest in this study.

Figures

Figure 1
Figure 1. The survival curves of tumor deposits (Absent / Present) plotted by the Kaplan-Meier method in rectal cancer with preoperative radiotherapy
Patients with tumor deposits had significantly worse rectal cancer-specific survival compared with those without tumor deposits.
Figure 2
Figure 2. The survival curves of tumor deposits (Absent / Present) plotted by the Kaplan-Meier method in regional lymph nodes negative rectal cancer with preoperative radiotherapy
Patients with tumor deposits (categorized as N1c category) had significantly worse rectal cancer-specific survival compared with those without tumor deposits (N0 category).
See this image and copyright information in PMC

References

    1. Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016 - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7–30. - PubMed
    1. Chen W, Zheng R, Zeng H, Zhang S. The updated incidences and mortalities of major cancers in China, 2011. Chin J Cancer. 2015;34:53. - PMC - PubMed
    1. Heald RJ, Ryall RD. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet. 1986;1:1479–1482. - PubMed
    1. Gerard JP, Conroy T, Bonnetain F, Bouche O, Chapet O, Closon-Dejardin MT, Untereiner M, Leduc B, Francois E, Maurel J, Seitz JF, Buecher B, Mackiewicz R, Ducreux M, Bedenne L. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol. 2006;24:4620–4625. - PubMed

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