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Meta-Analysis
. 2016 Nov 22;7(47):78180-78205.
doi: 10.18632/oncotarget.12102.

Management of advanced gastric cancer: An overview of major findings from meta-analysis

Xiaolong Qi  1 , Yanna Liu  1 , Wei Wang  2 , Danxian Cai  1 , Wende Li  3 , Jialiang Hui  1 , Chuan Liu  1 , Yanxia Zhao  4 , Guoxin Li  1
Affiliations
Meta-Analysis

Management of advanced gastric cancer: An overview of major findings from meta-analysis

Xiaolong Qi et al. Oncotarget. .

Abstract

This study aims to provide an overview of different treatment for advanced gastric cancer. In the present study, we systematically reviewed the major findings from relevant meta-analyses. A total of 54 relevant papers were searched via the PubMed, Web of Science, and Google scholar databases. They were classified according to the mainstay treatment modalities such as surgery, chemotherapy and others. Primary outcomes including overall survival, response rate, disease-free survival, recurrence-free survival, progression-free survival, time-to-progression, time-to failure, recurrence and safety were summarized. The recommendations and uncertainties regarding the treatment of advanced gastric cancer were also proposed. It was suggested that laparoscopic gastrectomy was a safe and technical alternative to open gastrectomy. Besides, neoadjuvant chemotherapy and adjuvant chemotherapy were thought to benefit the survival over surgery alone. And it was demonstrated in the study that targeted therapy like anti-angiogenic and anti-HER2 agents but anti-EGFR agent might have a significant survival benefit.

Keywords: advanced gastric cancer; chemotherapy; management; meta-analysis; surgery.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors have declared that no conflicts of interest

Figures

Figure 1
Figure 1. Flowchart of study inclusion
See this image and copyright information in PMC

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