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Review
. 2016 Aug 19:11:9-15.
doi: 10.1016/j.amsu.2016.07.019. eCollection 2016 Nov.

The TNBS-induced colitis animal model: An overview

Efstathios Antoniou  1 , Georgios Antonios Margonis  1 , Anastasios Angelou  2 , Anastasia Pikouli  2 , Paraskevi Argiri  3 , Ioannis Karavokyros  2 , Apostolos Papalois  4 , Emmanouil Pikoulis  2
Affiliations
Review

The TNBS-induced colitis animal model: An overview

Efstathios Antoniou et al. Ann Med Surg (Lond). .

Abstract

Background: Despite recent advances the pathogenesis of Crohn's disease remains incompletely understood. A variety of animal models have been utilized in an effort to provide further insights and develop more therapeutic options. In order to simulate, to an extent, the pathogenesis and the clinical course of the disease, TNBS induced colitis is often used. Various approaches for inducing TNBS -colitis have been described in the literature.

Methods/results: In this review, we sought to present the animal model of TNBS induced colitis and outline the pathogenesis, pathophysiology, clinical course and pathological characteristics of the model. Furthermore, we describe the differences among those protocols regarding types of animals and colitis induction.

Data sources: The MEDLINE database was thoroughly searched using the keywords: TNBS, colitis, Crohn's disease, animal model. Two investigators independently reviewed the abstracts and appropriate articles were included in this review. Additional articles were gathered and evaluated.

Conclusion: The aim of this study was to thoroughly present an updated review of the TNBS-induced colitis protocols that are implemented by researchers.

Keywords: Animal model; Colitis; Crohn's disease; TNBS.

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Figures

Fig. 1
Fig. 1
Severe colitis with ulceration.
Fig. 2
Fig. 2
Colitis with intraluminal abscesses.
See this image and copyright information in PMC

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