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. 2016:2016:2539320.
doi: 10.1155/2016/2539320. Epub 2016 Aug 30.

Neurogenic Bladder Repair Using Autologous Mesenchymal Stem Cells

Pradeep V Mahajan  1 , Swetha Subramanian  1 , Amit Danke  1 , Anand Kumar  1
Affiliations

Neurogenic Bladder Repair Using Autologous Mesenchymal Stem Cells

Pradeep V Mahajan et al. Case Rep Urol. 2016.

Abstract

The normal function of the urinary bladder is to store and expel urine in a coordinated, controlled fashion, the activity of which is regulated by the central and peripheral nervous systems. Neurogenic bladder is a term applied to a malfunctioning urinary bladder due to neurologic dysfunction or insult emanating from internal or external trauma, disease, or injury. This report describes a case of neurogenic bladder following laminectomy procedure and long-standing diabetes mellitus with neuropathy treated with autologous cellular therapy. The differentiation potential and paracrine effects of mesenchymal stem cells on bladder function have been highlighted.

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Figures

Figure 1
Figure 1
Pressure-flow study report: pretreatment.
Figure 2
Figure 2
Pressure-flow study report: posttreatment.
See this image and copyright information in PMC

References

    1. Andersen J. T., Bradley W. E. Neurogenic bladder dysfunction in protruded lumbar disk and after laminectomy. Urology. 1976;8(1):94–96. doi: 10.1016/0090-4295(76)90068-6. - DOI - PubMed
    1. Golbidi S., Laher I. Bladder dysfunction in diabetes mellitus. Frontiers in Pharmacology. 2010;1, article 136 doi: 10.3389/fphar.2010.00136. - DOI - PMC - PubMed
    1. Mousa N. A., Abou-Taleb H. A., Orabi H. Stem cell applications for pathologies of the urinary bladder. World Journal of Stem Cells. 2015;7(5):815–822. - PMC - PubMed
    1. Shukla D., Box G. N., Edwards R. A., Tyson D. R. Bone marrow stem cells for urologic tissue engineering. World Journal of Urology. 2008;26(4):341–349. doi: 10.1007/s00345-008-0311-y. - DOI - PubMed
    1. Ohta M., Suzuki Y., Noda T., et al. Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation. Experimental Neurology. 2004;187(2):266–278. doi: 10.1016/j.expneurol.2004.01.021. - DOI - PubMed