Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Seung-Hwan Lee¹, Janice M Zabolotny², Hu Huang³, Hyon Lee⁴, Young-Bum Kim⁵

Affiliations

¹ Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Ave., Boston, MA 02216, USA; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, South Korea. Electronic address: hwanx2@catholic.ac.kr.
² Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Ave., Boston, MA 02216, USA. Electronic address: jzabolot@bidmc.harvard.edu.
³ Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Ave., Boston, MA 02216, USA; Human Performance Laboratory, Department of Kinesiology and Physiology, East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Dr., Greenville, NC 27858, USA. Electronic address: huangh@ecu.edu.
⁴ Department of Neurology, Neuroscience Research Institute, Gachon University Gil Medical Center, 21 Namdong-daero 774 beon-gil, Namdong-gu, Incheon 21565, South Korea. Electronic address: hyonlee@gilhospital.com.
⁵ Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Ave., Boston, MA 02216, USA. Electronic address: ykim2@bidmc.harvard.edu.

PMID: 27656397
PMCID: PMC5021669
DOI: 10.1016/j.molmet.2016.06.011

Review

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Seung-Hwan Lee et al. Mol Metab. 2016.

. 2016 Jun 29;5(8):589-601.

doi: 10.1016/j.molmet.2016.06.011. eCollection 2016 Aug.

Authors

Seung-Hwan Lee¹, Janice M Zabolotny², Hu Huang³, Hyon Lee⁴, Young-Bum Kim⁵

Affiliations

¹ Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Ave., Boston, MA 02216, USA; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, South Korea. Electronic address: hwanx2@catholic.ac.kr.
² Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Ave., Boston, MA 02216, USA. Electronic address: jzabolot@bidmc.harvard.edu.
³ Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Ave., Boston, MA 02216, USA; Human Performance Laboratory, Department of Kinesiology and Physiology, East Carolina Diabetes and Obesity Institute, East Carolina University, 115 Heart Dr., Greenville, NC 27858, USA. Electronic address: huangh@ecu.edu.
⁴ Department of Neurology, Neuroscience Research Institute, Gachon University Gil Medical Center, 21 Namdong-daero 774 beon-gil, Namdong-gu, Incheon 21565, South Korea. Electronic address: hyonlee@gilhospital.com.
⁵ Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Ave., Boston, MA 02216, USA. Electronic address: ykim2@bidmc.harvard.edu.

PMID: 27656397
PMCID: PMC5021669
DOI: 10.1016/j.molmet.2016.06.011

Abstract

Background: Insulin, a pleotrophic hormone, has diverse effects in the body. Recent work has highlighted the important role of insulin's action in the nervous system on glucose and energy homeostasis, memory, and mood.

Scope of review: Here we review experimental and clinical work that has broadened the understanding of insulin's diverse functions in the central and peripheral nervous systems, including glucose and body weight homeostasis, memory and mood, with particular emphasis on intranasal insulin.

Major conclusions: Implications for the treatment of obesity, type 2 diabetes, dementia, and mood disorders are discussed in the context of brain insulin action. Intranasal insulin may have potential in the treatment of central nervous system-related metabolic disorders.

Keywords: Insulin; Intranasal insulin; Memory; Metabolism; Mood.

PubMed Disclaimer

References

1. Samuel V.T., Shulman G.I. Mechanisms for insulin resistance: common threads and missing links. Cell. 2012;148:852–871. - PMC - PubMed
1. Schwartz M.W., Porte D., Jr. Diabetes, obesity, and the brain. Science. 2005;307:375–379. - PubMed
1. Plum L., Schubert M., Bruning J.C. The role of insulin receptor signaling in the brain. Trends in Endocrinology and Metabolism. 2005;16:59–65. - PubMed
1. Choi K., Kim Y.B. Molecular mechanism of insulin resistance in obesity and type 2 diabetes. Korean Journal of Internal Medicine. 2010;25:119–129. - PMC - PubMed
1. Havrankova J., Roth J., Brownstein M. Insulin receptors are widely distributed in the central nervous system of the rat. Nature. 1978;272:827–829. - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Affiliations

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Authors

Affiliations

Abstract

References

Publication types

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials