Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Aug;10(8):BC09-13.
doi: 10.7860/JCDR/2016/20715.8347. Epub 2016 Aug 1.

Plasma Myeloperoxidase and Total Sialic Acid as Prognostic Indicators in Acute Coronary Syndrome

Sumitra Govindarajan  1 , Vm Mithun Raghavan  2 , Anand C Vasudeva Rao  3
Affiliations

Plasma Myeloperoxidase and Total Sialic Acid as Prognostic Indicators in Acute Coronary Syndrome

Sumitra Govindarajan et al. J Clin Diagn Res. 2016 Aug.

Abstract

Introduction: Acute Coronary Syndrome (ACS) is the leading cause of death worldwide. Oxidative stress and inflammation play important role in the destabilization of plaques leading to ACS. Markers which reflect this pathophysiologic mechanism may have prognostic value. Myeloperoxidase (MPO) and Sialic acid are markers of inflammation and oxidative stress. Both these markers are increased in patients with ACS. Their prognostic value in ACS is not well established.

Aim: To analyse the prognostic value of plasma myeloperoxidase and total sialic acid levels in patients with suspected acute coronary syndrome.

Materials and methods: A prospective study was conducted on 93 consecutively admitted patients with chest pain from July 2011 to September 2011. Plasma MPO and total sialic acid levels on admission were estimated spectrophotometrically. These were compared with extent of disease, development of complications during the hospital stay, left ventricular ejection fraction and mean duration of stay in hospital.

Results: Plasma MPO and total sialic acid levels were significantly higher in patients with myocardial infarction than those with unstable and stable angina (p<0.001 and p<0.007 respectively). The levels of plasma MPO and sialic acid levels were significantly higher in patients who developed complications like heart failure, arrhythmias, renal failure during their stay in hospital (p<0.011 and p<0.006 respectively). Ejection fraction was significantly low in patients with high MPO levels (p<0.011).

Conclusion: In patients with ACS, plasma MPO and total sialic acid levels on admission could predict the development of complications during their hospital stay. MPO levels correlated with ejection fraction in patients with ACS.

Keywords: Left ventricular ejection fraction; Major adverse cardiac event; Myocardial infarction.

PubMed Disclaimer

Figures

[Table/Fig-4]:
[Table/Fig-4]:
Correlation of plasma MPO levels with ejection fraction.
[Table/Fig-5]:
[Table/Fig-5]:
Correlation of plasma MPO levels with duration of stay in hospital.
[Table/Fig-7]:
[Table/Fig-7]:
Correlation of plasma sialic acid levels with ejection fraction.
[Table/Fig-8]:
[Table/Fig-8]:
Correlation of plasma sialic acid levels with duration of stay in hospital.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Finegold JA, Asaria P, Francis DP. Mortality from ischaemic heart disease by country, region, and age: statistics from world health organisation and united nations. International Journal of Cardiology. 2013;168(2):934–45. - PMC - PubMed
    1. Cannon C. Evidence-based risk stratification to target therapies in acute coronary syndromes. Circulation. 2002;106(13):1588–91. - PubMed
    1. Bugiardini R. Risk stratification in acute coronary syndrome: focus on unstable angina/non-ST segment elevation myocardial infarction. Heart. 2004;90(7):729–31. - PMC - PubMed
    1. Vitulli P, Tanzilli G, Marullo AGM, Peruzzi, M, Biondi Zoccai G. Inflammation and oxidative stress in acute coronary syndromes: a continuum from plaque vulnerability to thrombus formation. enliven. Clinical Cardiology and Research. 2014;1(3):005.
    1. Libby P, Tabas I, Fredman G, Fisher E. Inflammation and its resolution as determinants of acute coronary syndromes. Circulation Research. 2014;114(12):1867–79. - PMC - PubMed

LinkOut - more resources