Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Aug;10(8):DC09-11.
doi: 10.7860/JCDR/2016/19958.8339. Epub 2016 Aug 1.

Antifungal Activity of Cinnamon Oil and Olive Oil against Candida Spp. Isolated from Blood Stream Infections

Nidhi Goel  1 , Hina Rohilla  2 , Gajender Singh  3 , Parul Punia  2
Affiliations

Antifungal Activity of Cinnamon Oil and Olive Oil against Candida Spp. Isolated from Blood Stream Infections

Nidhi Goel et al. J Clin Diagn Res. 2016 Aug.

Abstract

Introduction: Recently non-albicans Candida has emerged as a major cause of morbidity and mortality in blood stream infections. Some species of the Candida are becoming increasingly resistant to first line and second line antifungals such as echinocandins and fluconazole. In view of increasing global antifungal resistance, role of alternative and better antifungals like natural plant products need to be explored. Essential oils are known to exhibit antimicrobial activity against various fungi. Hence, we evaluated the efficacy of cinnamon oil and olive oil against Candida spp.

Aim: To evaluate the invitro antifungal activity of olive oil and cinnamon oil against blood stream Candida isolates.

Materials and methods: The present prospective observational study was conducted in the Department of Microbiology at a tertiary care teaching hospital during one year June 2011-July 2012. Blood samples were collected from 1376 patients clinically suspected to have fungal septicaemia, out of which 100 (7.2%) Candida isolates obtained, were speciated by conventional methods. Antifungal susceptibility testing of all the isolates was done against fluconazole, voriconazole as per NCCL (M27-A2) and against olive oil and cinnamon oil by agar well diffusion method.

Results: Prevalence of Candidemia was 7.26%. C. albicans (85.3%) and C. parapsilosis (85.7%) were most sensitive to fluconazole followed by C. tropicalis (67.4%). All isolates were 100% sensitive to voriconazole. Both oils were found to be effective against nearly 50% of the Candida isolates. About 55.5% of fluconazole resistant C. krusei strains were sensitive to olive and cinnamon oil.

Conclusion: Fluconazole resistant non-albicans Candida has emerged as major cause of Candidemia. Cinnamon and olive oil show marked sensitivity against albicans and non-albicans spp.

Keywords: Antifungal susceptibility; Candidemia; Essential oil; Fluconazole.

PubMed Disclaimer

Figures

[Table/Fig-4]:
[Table/Fig-4]:
Predisposing risk factors among pediatric patients.
[Table/Fig-6]:
[Table/Fig-6]:
Resistance pattern of various condida isolates against antifungal drugs and oils.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Oberoi JK, Wattal C, Goel N, Raveendran R, Datta S, Prasad K. Non-albicans Candida species in blood stream infections in a tertiary care hospital at New Delhi, India. Indian J Med Res. 2012;136:997–1003. - PMC - PubMed
    1. Sanglard D. Emerging Threats in Antifungal-Resistant Fungal Pathogens. Frontiers in Medicine. 2016;3:11–13. - PMC - PubMed
    1. Upadhyay RK, Dwivedi P, Ahmad S. Screening of antibacterial activity of six plant essential oils against pathogenic bacterial strains. Asian J Med Sci. 2010;2:152–58.
    1. Rathi SG, Bhaskar VH, Patel PG. Invitro Anti fungal Screening of Embelia ribes Plant Extract through EUCAST Method. Int J PharmaSci and Research. 2010;1:134–38.
    1. Milne LJR. Mackie and McCartney: Practical Medical Microbiology. 14th ed. New York: Churchill Livingstone; 1996. Fungi. In: Collee JG, Fraser AG, Marimon BP, Simmons A, editors; pp. 714–17.

LinkOut - more resources