Case Reports
doi: 10.7860/JCDR/2016/19694.8316.
Epub 2016 Aug 1.
Cefoperazone Induced Gastrointestinal Bleeding
Affiliations
- PMID: 27656491
- PMCID: PMC5028500
- DOI: 10.7860/JCDR/2016/19694.8316
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Case Reports
Cefoperazone Induced Gastrointestinal Bleeding
J Clin Diagn Res.
2016 Aug.
Abstract
Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient's coagulation function disorder and her use of the suspect drug.
Keywords: Cefoperazone; Coagulopathy; Vitamin K.
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