Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Aug;10(8):ZD38-40.
doi: 10.7860/JCDR/2016/20013.8362. Epub 2016 Aug 1.

Desmoplastic Ameloblastoma Arising in a Dentigerous Cyst - A Case Report and Discussion

Muruganandhan Jayanandan  1 , Shaik Mohamed Shamsudeen  2 , Satish Kumar Srinivasan  2 , S Nalin Kumar  3 , Tyson Babu Pulikkottil  4
Affiliations
Case Reports

Desmoplastic Ameloblastoma Arising in a Dentigerous Cyst - A Case Report and Discussion

Muruganandhan Jayanandan et al. J Clin Diagn Res. 2016 Aug.

Abstract

Dentigerous cyst is a fairly common odontogenic cyst with an uncomplicated prognosis. However, reports of odontogenic and non-odontogenic tumors arising from the cysts have been published for many years. Therefore, the importance of thorough histopathological examination and regular follow-up cannot be overemphasized. Here is a case report of a possible development of desmoplastic ameloblastoma from a dentigerous cyst. This case is unique for two main reasons. Firstly, to our knowledge such a case has not been reported previously. Secondly, the tumor seemed to arise from the capsule and not from lining of the dentigerous cyst. Transformation of odontogenic rests into cysts is known to occur in the syndromic cases of odontogenic keratocysts (resulting in recurrent and daughter cysts) but not in dentigerous cysts. This case report may prompt greater interest in the role of the supposedly inactive odontogenic nests in the capsule of these cysts.

Keywords: Cyst-tumor transformation; Desmoplasia; Odontogenic cyst; Odontogenic tumor.

PubMed Disclaimer

Figures

[Table/Fig-1]:
[Table/Fig-1]:
Orthopantomograph of the patient showing radiolucency around the crown of impacted 45.
[Table/Fig-2]:
[Table/Fig-2]:
Post-surgical photograph.
[Table/Fig-3]:
[Table/Fig-3]:
Gross specimen before processing.
[Table/Fig-4]:
[Table/Fig-4]:
Photomicrograph showing the cyst lining and capsule – hematoxylin and eosin, 10X magnification.
[Table/Fig-5a,b]:
[Table/Fig-5a,b]:
Photomicrograph showing the odontogenic nests – hematoxylin and eosin, 4X and 10X magnification respectively.
[Table/Fig-6a,b]:
[Table/Fig-6a,b]:
Photomicrograph showing the desmoplastic focus – hematoxylin and eosin, 4X and 10X magnification respectively.
[Table/Fig-7]:
[Table/Fig-7]:
Photomicrograph showing the ameloblastic cells – hematoxylin and eosin, 40X magnification.
[Table/Fig-8a,b]:
[Table/Fig-8a,b]:
Photomicrograph showing the stromal induction of the epithelial cells – Hematoxylin and eosin, 40X magnification.
[Table/Fig-9]:
[Table/Fig-9]:
Photomicrograph showing osseous metaplasia – hematoxylin and eosin, 10X magnification.
[Table/Fig-10]:
[Table/Fig-10]:
Six month follow-up OPG.
See this image and copyright information in PMC

References

    1. Gorlin RJ, Vickers RA, Kelln E, Williamson JJ. The multiple basal-cell nevi syndrome-an analysis of a syndrome consisting of multiple nevoid basal-cell carcinoma, jaw cysts, skeletal anomalies, medulloblastoma, and hypo responsiveness to parathormone. Cancer. 1965;18:89–104. - PubMed
    1. Stoelinga PJ, Peters JH, van de Staak WJ, Cohen MM Jr. Some new findings in the basal-cell nevus syndrome. Oral Surg Oral Med Oral Pathol. 1973;36:686–92. - PubMed
    1. Eversole LR, Sabes WR, Rovin S. Aggressive growth and neoplastic potential of odontogenic cysts: with special reference to central epidermoid and mucoepidermoid carcinomas. Cancer. 1975;35:270–82. - PubMed
    1. Neville BW, Damm DD, Allen CM, Chi A. Oral and Maxillofacial Pathology. First South Asia edition. India: Reed Elsevier; 2015.
    1. Shear M, Speight P. Cysts of the oral and maxillofacial regions. New York: John Wiley & Sons; 2008.

Publication types

LinkOut - more resources