Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses' Health Study

Seungyoun Jung^{1

2

3}, Stephanie A Smith-Warner^{4

5}, Walter C Willett^{6

7

8}, Molin Wang⁹, Tianying Wu¹⁰, Majken Jensen^{11

12}, Susan E Hankinson^{13

14}, A Heather Eliassen^{15

16}

Affiliations

¹ Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. sjung@epi.umaryland.edu.
² Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. sjung@epi.umaryland.edu.
³ Department of Epidemiology and Public Health, University of Maryland Baltimore School of Medicine, Baltimore, MD 21201, USA. sjung@epi.umaryland.edu.
⁴ Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. swarner@hsph.harvard.edu.
⁵ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. swarner@hsph.harvard.edu.
⁶ Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. wwillett@hsph.harvard.edu.
⁷ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. wwillett@hsph.harvard.edu.
⁸ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. wwillett@hsph.harvard.edu.
⁹ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. stmow@channing.harvard.edu.
¹⁰ Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45219, USA. wutg@ucmail.uc.edu.
¹¹ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. majken.jensen@channing.harvard.edu.
¹² Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. majken.jensen@channing.harvard.edu.
¹³ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. sue.hankinson@channing.harvard.edu.
¹⁴ Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA 01003, USA. sue.hankinson@channing.harvard.edu.
¹⁵ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. nhahe@channing.harvard.edu.
¹⁶ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. nhahe@channing.harvard.edu.

PMID: 27657128
PMCID: PMC5037570
DOI: 10.3390/nu8090587

Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses' Health Study

Seungyoun Jung et al. Nutrients. 2016.

. 2016 Sep 21;8(9):587.

doi: 10.3390/nu8090587.

Authors

Seungyoun Jung^{1

2

3}, Stephanie A Smith-Warner^{4

5}, Walter C Willett^{6

7

8}, Molin Wang⁹, Tianying Wu¹⁰, Majken Jensen^{11

12}, Susan E Hankinson^{13

14}, A Heather Eliassen^{15

16}

Affiliations

¹ Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. sjung@epi.umaryland.edu.
² Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. sjung@epi.umaryland.edu.
³ Department of Epidemiology and Public Health, University of Maryland Baltimore School of Medicine, Baltimore, MD 21201, USA. sjung@epi.umaryland.edu.
⁴ Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. swarner@hsph.harvard.edu.
⁵ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. swarner@hsph.harvard.edu.
⁶ Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. wwillett@hsph.harvard.edu.
⁷ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. wwillett@hsph.harvard.edu.
⁸ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. wwillett@hsph.harvard.edu.
⁹ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. stmow@channing.harvard.edu.
¹⁰ Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45219, USA. wutg@ucmail.uc.edu.
¹¹ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. majken.jensen@channing.harvard.edu.
¹² Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. majken.jensen@channing.harvard.edu.
¹³ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. sue.hankinson@channing.harvard.edu.
¹⁴ Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA 01003, USA. sue.hankinson@channing.harvard.edu.
¹⁵ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. nhahe@channing.harvard.edu.
¹⁶ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. nhahe@channing.harvard.edu.

PMID: 27657128
PMCID: PMC5037570
DOI: 10.3390/nu8090587

Abstract

Healthy diets may lower oxidative stress and risk of chronic diseases. However, no previous studies examined associations between diet and fluorescent oxidation products (FlOP), a global marker of oxidative stress. We evaluated associations between healthy eating patterns (Alternative Healthy Eating Index (AHEI), Dietary Approach to Stop Hypertension (DASH), and Alternate Mediterranean Diet (aMED)) and FlOP, measured at three excitation/emission wavelengths (FlOP_360, FlOP_320, FlOP_400) from 2021 blood samples collected from 1688 women within the Nurses' Health Study. AHEI, DASH, and aMED scores were significantly positively associated with FlOP_360 and FlOP_320 concentrations (p-trend ≤ 0.04), but not associated with FlOP_400. Among specific food groups that contribute to these diet scores, significantly positive associations were observed with legumes and vegetables for FlOP_360, vegetables and fruits for FlOP_320, and legumes and alcohol for FlOP_400. Inverse associations were observed with nuts, sweets or desserts, and olive oil for FlOP_360, nuts for FlOP_320 and sweets or desserts for FlOP_400 (all p-trend ≤ 0.05). However, FlOP variation due to diet was small compared to overall FlOP variation. In conclusion, AHEI, DASH, and aMED scores were unexpectedly positively, but weakly, associated with FlOP_360 and FlOP_320. However, these findings should be interpreted cautiously as the determinants of FlOP concentrations are not fully understood.

Keywords: epidemiology; fluorescent oxidation products; healthy eating pattern; nutrition; oxidative stress.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Cited by

Long-term diet quality and its change in relation to late-life subjective cognitive decline.
Yuan C, Cao Y, Ascherio A, Okereke OI, Zong G, Grodstein F, Hofman A, Willett WC. Yuan C, et al. Am J Clin Nutr. 2022 Jan 11;115(1):232-243. doi: 10.1093/ajcn/nqab326. Am J Clin Nutr. 2022. PMID: 34562097 Free PMC article.
Unhealthy lifestyle and oxidative damage in childhood obesity.
De Giuseppe R, Calcaterra V, Biino G, Manuelli M, Mier NR, Mantelli M, De Filippo M, Cossellu G, Cena H. De Giuseppe R, et al. Eat Weight Disord. 2020 Apr;25(2):481-486. doi: 10.1007/s40519-018-0626-7. Epub 2018 Dec 15. Eat Weight Disord. 2020. PMID: 30554325
Global biomarkers of oxidative stress and fractures: a matched case-control study.
Yang S, Feng L, Lix LM, Leslie WD, Guo D, Shi X, Yuan B. Yang S, et al. Front Endocrinol (Lausanne). 2023 Jun 23;14:1179521. doi: 10.3389/fendo.2023.1179521. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37448464 Free PMC article.
New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress.
Ferro D, Baratta F, Pastori D, Cocomello N, Colantoni A, Angelico F, Del Ben M. Ferro D, et al. Nutrients. 2020 Sep 10;12(9):2762. doi: 10.3390/nu12092762. Nutrients. 2020. PMID: 32927776 Free PMC article. Review.
Association between healthy dietary patterns and markers of oxidative stress in the Sister Study.
Crawford B, Steck SE, Sandler DP, Nichols HB, Milne GL, Park YM. Crawford B, et al. Eur J Nutr. 2024 Mar;63(2):485-499. doi: 10.1007/s00394-023-03280-z. Epub 2023 Dec 9. Eur J Nutr. 2024. PMID: 38070016

See all "Cited by" articles

References

1. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Boil. 2007;39:44–84. doi: 10.1016/j.biocel.2006.07.001. - DOI - PubMed
1. Valko M., Rhodes C.J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 2006;160:1–40. doi: 10.1016/j.cbi.2005.12.009. - DOI - PubMed
1. Roubal W.T., Tappel A.L. Polymerization of proteins induced by free-radical lipid peroxidation. Arch. Biochem. Biophys. 1966;113:150–155. doi: 10.1016/0003-9861(66)90168-8. - DOI - PubMed
1. Holt E.M., Steffen L.M., Moran A., Basu S., Steinberger J., Ross J.A., Hong C.P., Sinaiko A.R. Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. J. Am. Diet. Assoc. 2009;109:414–421. doi: 10.1016/j.jada.2008.11.036. - DOI - PMC - PubMed
1. Gupta R.K., Patel A.K., Shah N., Chaudhary A.K., Jha U.K., Yadav U.C., Gupta P.K., Pakuwal U. Oxidative stress and antioxidants in disease and cancer: A review. Asian Pac. J. Cancer Prev. 2014;15:4405–4409. doi: 10.7314/APJCP.2014.15.11.4405. - DOI - PubMed

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses' Health Study

Affiliations

Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses' Health Study

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources