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. 2016 Jan;7(2):74-81.
doi: 10.2500/ar.2016.7.0163.

Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis

Bhushan Chauhan  1 , Manish Gupta, Komal Chauhan
Affiliations

Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis

Bhushan Chauhan et al. Allergy Rhinol (Providence). 2016 Jan.

Abstract

Background: Antioxidants have a preventive or therapeutic role in oxygen free radical-mediated cell and tissue damage. The study aimed to investigate the therapeutic effects of antioxidants and intranasal steroid fluticasone furoate (FF) on the clinical outcome of patients with perennial allergic rhinitis.

Methods: Subjects with perennial allergic rhinitis (n = 61) were randomly divided into two groups, group A (n = 30) received FF and group B (n = 31) received FF with antioxidants for 6 weeks. Nasal and ocular symptoms were evaluated weekly by using a four-point categoric scale. The efficacy of the study drug was assessed based on the mean change from baseline of the total daytime nasal symptom scores, total nighttime nasal symptom scores, and the composite symptom scores.

Results: The combined therapy (FF with antioxidants) resulted in marked improvements (p ≤ 0.05) in the mean total daytime nasal symptom scores, total nighttime nasal symptom scores, and composite symptom scores of subjects compared with ones treated with intranasal steroid (FF) alone, which highlighted the therapeutic effect of antioxidants in allergic rhinitis.

Conclusion: Significant improvement in clinical outcome was observed in subjects who received antioxidants along with FF. However, because this was an open-label study, the results must be interpreted with caution, and further double-blind, placebo-controlled, dose-ranging trials supplemented with different antioxidants together with intranasal steroids are suggested.

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Conflict of interest statement

The authors have no conflicts of interest to declare pertaining to this article

Figures

Figure 1.
Figure 1.
Study design.
Figure 2.
Figure 2.
Weekly mean scores of daytime nasal symptom scores.
Figure 3.
Figure 3.
Weekly mean scores of nighttime nasal symptom scores.
Figure 4.
Figure 4.
Weekly mean composite scores of day- and nighttime nasal symptom scores.
See this image and copyright information in PMC

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