Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Dec;87(sup363):6-14.
doi: 10.1080/17453674.2016.1235087. Epub 2016 Sep 23.

Cellular senescence in aging and osteoarthritis

Wei Seong Toh  1   2 , Mats Brittberg  3   4 , Jack Farr  5 , Casper Bindzus Foldager  6 , Andreas H Gomoll  7 , James Hoi Po Hui  2   8 , James B Richardson  9   10 , Sally Roberts  9   10 , Myron Spector  11   12
Affiliations
Review

Cellular senescence in aging and osteoarthritis

Wei Seong Toh et al. Acta Orthop. 2016 Dec.

Abstract

- It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis. Cellular senescence, the loss of the ability of cells to divide, has been noted as the major factor contributing to age-related changes in cartilage homeostasis, function, and response to injury. The underlying mechanisms of cellular senescence, while not fully understood, have been associated with telomere erosion, DNA damage, oxidative stress, and inflammation. In this review, we discuss the causes and consequences of cellular senescence, and the associated biological challenges in cartilage repair. In addition, we present novel strategies for modulation of cellular senescence that may help to improve cartilage regeneration in an aging population.

PubMed Disclaimer

Figures

None
Diagram summarizing the strategies that may be used to overcome the problem of cellular senescence.
See this image and copyright information in PMC

References

    1. Adesida A, Mulet-Sierra A, Jomha N.. Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells. Stem Cell Res Ther 2012; 3 (2): 9. - PMC - PubMed
    1. Adkisson H D, Martin J A, Amendola R L, Milliman C, Mauch K A, Katwal A B, et al. The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. Am J Sports Med 2010; 38 (7): 1324–33. - PMC - PubMed
    1. Afizah H, Yang Z, Hui J H P, Ouyang H-W, Lee E-H.. A comparison between the chondrogenic potential of human bone marrow stem cells (BMSCs) and adipose-derived stem cells (ADSCs) taken from the same donors. Tissue Eng 2007; 13 (4): 659–66. - PubMed
    1. Ashraf S, Cha B H, Kim J S, Ahn J, Han I, Park H, et al. Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration. Osteoarthritis Cartilage 2016; 24 (2): 196–205. - PubMed
    1. Bae Y-U, Choi J-H, Nagy A, Sung H-K, Kim J-R.. Antisenescence effect of mouse embryonic stem cell conditioned medium through a PDGF/FGF pathway. FASEB J 2016; 30 (3): 1276–86. - PubMed

MeSH terms

LinkOut - more resources