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Comment
. 2016 Oct 4;113(40):11066-11068.
doi: 10.1073/pnas.1613437113. Epub 2016 Sep 22.

Placenta plays a critical role in maternal-fetal resource allocation

Affiliations
Comment

Placenta plays a critical role in maternal-fetal resource allocation

Thomas Jansson. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The role of the placenta in maternal–fetal resource allocation. Placental function adapts in response to maternal nutritional cues, nutrient sensing signaling pathways intrinsic to the placenta, and fetal-demand signals. As a result, fetal oxygen and nutrient delivery changes, affecting fetal growth and programming the fetus for disease later in life. The figure highlights the findings of Sferruzzi-Perri et al. (7), demonstrating an important role of maternal and fetal PI3K signaling in regulating maternal-fetal resource allocation. UPBF, utero–placental blood flow. Modified from ref. , with permission from Elsevier.

Comment on

References

    1. Gluckman PD, Hanson MA. Living with the past: Evolution, development, and patterns of disease. Science. 2004;305(5691):1733–1736. - PubMed
    1. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359(1):61–73. - PMC - PubMed
    1. Hales CN, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991;303(6809):1019–1022. - PMC - PubMed
    1. Barker DJP, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986;1(8489):1077–1081. - PubMed
    1. Jansson T, Powell TL. IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: Does the placenta function as a nutrient sensor? A review. Placenta. 2006;27(SupplA):S91–S97. - PubMed

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