doi: 10.1016/0304-3835(89)90126-2.
Induction of rat liver glutathione transferase subunit 7 by lead nitrate
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- PMID: 2766257
- DOI: 10.1016/0304-3835(89)90126-2
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Induction of rat liver glutathione transferase subunit 7 by lead nitrate
Cancer Lett.
1989 Aug.
Abstract
The effect of a single dose of lead nitrate (10 microM/100 g body wt), a hepatic mitogen, on rat liver glutathione transferase (GST) subunit expression was investigated. Using SDS-polyacrylamide gel electrophoresis and Western blot technique evidence for the induction of GST 7-7 is shown. This occurrence is identical to that observed in preneoplastic nodules generated in rat liver by different models of chemical carcinogenesis, suggesting that lead nitrate may be a very simple model for investigation of the mechanism of glutathione transferase 7-7 gene expression in chemical hepatocarcinogenesis.
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