Regulation of pulmonary endothelial barrier function by kinases

doi:10.1152/ajplung.00233.2016

Review

. 2016 Nov 1;311(5):L832-L845.

doi: 10.1152/ajplung.00233.2016. Epub 2016 Sep 23.

Regulation of pulmonary endothelial barrier function by kinases

Nektarios Barabutis¹, Alexander Verin², John D Catravas^{3

4}

Affiliations

¹ Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia.
² Vascular Biology Center, Augusta University, Augusta, Georgia; and.
³ Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, jcatrava@odu.edu.
⁴ School of Medical Diagnostic and Translational Sciences, College of Health Sciences, Old Dominion University, Norfolk, Virginia.

PMID: 27663990
PMCID: PMC5130537
DOI: 10.1152/ajplung.00233.2016

Review

Regulation of pulmonary endothelial barrier function by kinases

Nektarios Barabutis et al. Am J Physiol Lung Cell Mol Physiol. 2016.

. 2016 Nov 1;311(5):L832-L845.

doi: 10.1152/ajplung.00233.2016. Epub 2016 Sep 23.

Authors

Nektarios Barabutis¹, Alexander Verin², John D Catravas^{3

4}

Affiliations

¹ Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia.
² Vascular Biology Center, Augusta University, Augusta, Georgia; and.
³ Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, jcatrava@odu.edu.
⁴ School of Medical Diagnostic and Translational Sciences, College of Health Sciences, Old Dominion University, Norfolk, Virginia.

PMID: 27663990
PMCID: PMC5130537
DOI: 10.1152/ajplung.00233.2016

Abstract

The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

Keywords: barrier function; endothelium; kinases; lung; permeability.

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Figures

**Fig. 1.**
Interaction among major kinase pathways in the pathophysiological control of endothelial barrier function. FAK, focal adhesion kinase; GAP, GTPase-activating protein; AMPK, AMP-activated protein kinase; PAK, p21-activated kinase; ROCK, RhoA-associated protein kinase; LIMK, LIM domain kinase; MLCK, myosin light chain kinase; pMLCK, phosphorylated MLCK; pcofilin, phosphorylated cofilin; MAPK, MAP kinase.

See this image and copyright information in PMC

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References

1. Abedi H, Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 272: 15442–15451, 1997. - PubMed
1. Abrahamsen H, Vang T, Tasken K. Protein kinase A intersects SRC signaling in membrane microdomains. J Biol Chem 278: 17170–17177, 2003. - PubMed
1. Abu-Ghazaleh R, Kabir J, Jia H, Lobo M, Zachary I. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861 and migration and anti-apoptosis in endothelial cells. Biochem J 360: 255–264, 2001. - PMC - PubMed
1. Adam AP. Regulation of endothelial adherens junctions by tyrosine phosphorylation. Mediators Inflamm 2015: 272858, 2015. - PMC - PubMed
1. Adamson RH, Sarai RK, Altangerel A, Thirkill TL, Clark JF, Curry FR. Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. Cardiovasc Res 88: 344–351, 2010. - PMC - PubMed

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[1] Abedi H, Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 272: 15442–15451, 1997. - PubMed

[2] Abedi H, Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 272: 15442–15451, 1997. - PubMed

[3] Abrahamsen H, Vang T, Tasken K. Protein kinase A intersects SRC signaling in membrane microdomains. J Biol Chem 278: 17170–17177, 2003. - PubMed

[4] Abrahamsen H, Vang T, Tasken K. Protein kinase A intersects SRC signaling in membrane microdomains. J Biol Chem 278: 17170–17177, 2003. - PubMed

[5] Abu-Ghazaleh R, Kabir J, Jia H, Lobo M, Zachary I. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861 and migration and anti-apoptosis in endothelial cells. Biochem J 360: 255–264, 2001. - PMC - PubMed

[6] Abu-Ghazaleh R, Kabir J, Jia H, Lobo M, Zachary I. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861 and migration and anti-apoptosis in endothelial cells. Biochem J 360: 255–264, 2001. - PMC - PubMed

[7] Adam AP. Regulation of endothelial adherens junctions by tyrosine phosphorylation. Mediators Inflamm 2015: 272858, 2015. - PMC - PubMed

[8] Adam AP. Regulation of endothelial adherens junctions by tyrosine phosphorylation. Mediators Inflamm 2015: 272858, 2015. - PMC - PubMed

[9] Adamson RH, Sarai RK, Altangerel A, Thirkill TL, Clark JF, Curry FR. Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. Cardiovasc Res 88: 344–351, 2010. - PMC - PubMed

[10] Adamson RH, Sarai RK, Altangerel A, Thirkill TL, Clark JF, Curry FR. Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. Cardiovasc Res 88: 344–351, 2010. - PMC - PubMed

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Regulation of pulmonary endothelial barrier function by kinases

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Regulation of pulmonary endothelial barrier function by kinases

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