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Review
. 2016 Nov;16(11):109.
doi: 10.1007/s11892-016-0806-7.

The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy

Chris Fraker  1 , Allison L Bayer  2   3
Affiliations
Review

The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy

Chris Fraker et al. Curr Diab Rep. 2016 Nov.

Abstract

Treatments for autoimmune diseases including type 1 diabetes (T1D) are aimed at resetting the immune system, especially its adaptive arm. The innate immune system is often ignored in the design of novel immune-based therapies. There is increasing evidence for multiple natural killer (NK) subpopulations, but their role is poorly understood in autoimmunity and likely is contributing to the controversial role reported for NKs. In this review, we will summarize NK subsets and their roles in tolerance, autoimmune diabetes, and immunotherapy.

Keywords: Diabetes; Natural killer cells; Tolerance.

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