Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Nov;16(11):110.
doi: 10.1007/s11892-016-0807-6.

Restoring Regulatory T Cells in Type 1 Diabetes

Allyson Spence  1 , Qizhi Tang  2
Affiliations
Free article
Review

Restoring Regulatory T Cells in Type 1 Diabetes

Allyson Spence et al. Curr Diab Rep. 2016 Nov.
Free article

Abstract

Genetic and cellular studies of type 1 diabetes in patients and in the nonobese diabetic mouse model of type 1 diabetes point to an imbalance between effector T cells and regulatory T cells (Tregs) as a driver of the disease. The imbalance may arise as a consequence of genetically encoded defects in thymic deletion of islet antigen-specific T cells, induction of islet antigen-specific thymic Tregs, unfavorable tissue environment for peripheral Treg induction, and failure of islet antigen-specific Tregs to survive in the inflamed islets secondary to insufficient IL-2 signals. These understandings are the foundation for rationalized design of new therapeutic interventions to restore the balance by selectively targeting effector T cells and boosting Tregs.

Keywords: CTLA-4; IL-2; Nonobese diabetic (NOD) mice; Regulatory T cells (Tregs); Therapy; Type 1 diabetes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nat Genet. 1993 Aug;4(4):404-9 - PubMed
    1. Diabetes. 2010 Feb;59(2):407-15 - PubMed
    1. J Immunol. 2015 Dec 1;195(11):5203-14 - PubMed
    1. Clin Immunol. 2015 Sep;160(1):3-13 - PubMed
    1. Am J Transplant. 2014 Jan;14(1):27-38 - PubMed