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Comment
. 2016 Sep 1;30(17):1909-10.
doi: 10.1101/gad.289587.116.

'Cold cuts' added to the circadian smorgasbord of regulatory mechanisms

Carla B Green  1
Affiliations
Comment

'Cold cuts' added to the circadian smorgasbord of regulatory mechanisms

Carla B Green. Genes Dev. .

Abstract

In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body temperature, and a new study by Gotic and colleagues (pp. 2005-2017) reveals a surprising and novel mechanism that involves temperature-dependent enhancement of splicing efficiency.

Keywords: Cirbp; circadian rhythms; splicing efficiency; temperature.

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References

    1. Brown SA, Zumbrunn G, Fleury-Olela F, Preitner N, Schibler U. 2002. Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Curr Biol 12: 1574–1583. - PubMed
    1. Buhr ED, Yoo SH, Takahashi JS. 2010. Temperature as a universal resetting cue for mammalian circadian oscillators. Science 330: 379–385. - PMC - PubMed
    1. Gotic I, Omidi S, Fleury-Olela F, Molina N, Naef F, Schibler U. 2016. Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp. Gene Dev (this issue) 10.1101/gad.287094.116. - DOI - PMC - PubMed
    1. Kornmann B, Schaad O, Bujard H, Takahashi JS, Schibler U. 2007. System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol 5: e34. - PMC - PubMed
    1. Morf J, Rey G, Schneider K, Stratmann M, Fujita J, Naef F, Schibler U. 2012. Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally. Science 338: 379–383. - PubMed

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