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. 2017 Jan 20;79(1):35-40.
doi: 10.1292/jvms.16-0009. Epub 2016 Sep 23.

Assessment of severity and changes in C-reactive protein concentration and various biomarkers in dogs with pancreatitis

Toru Sato  1 , Koichi Ohno, Takashi Tamamoto, Mariko Oishi, Hideyuki Kanemoto, Kenjiro Fukushima, Yuko Goto-Koshino, Masashi Takahashi, Hajime Tsujimoto
Affiliations

Assessment of severity and changes in C-reactive protein concentration and various biomarkers in dogs with pancreatitis

Toru Sato et al. J Vet Med Sci. .

Abstract

Canine pancreatitis is a relatively common disorder, and its mortality rate remains high. However, prognostic factors for pancreatitis based on evidence are limited. Moreover, the relationship between changes in C-reactive protein (CRP) concentration-an important prognostic factor for human patients with acute pancreatitis-and the prognosis of dogs with pancreatitis has not been widely studied. Therefore, we examined prognostic factors for canine pancreatitis during the first medical examination and evaluated the usefulness of serial CRP measurements during hospitalization. Sixty-five dogs met the inclusion criteria, including 22 that were hospitalized and treated. In Study 1, a multivariate analysis revealed that three factors- decreased platelet count and a marked (greater than 1,000 µg/l) elevation of specific canine pancreatic lipase (Spec cPL) concentration at the first medical examination, as well as elevated blood urea nitrogen (BUN) and/or creatinine (CRE) level-were significantly different between the survivors and nonsurvivors. Moreover, CRP concentrations on the third and fourth days were significantly different between the two groups in Study 2. An evaluation of the decreased platelet count, remarkable elevation of Spec cPL concentration at the first medical examination, elevation of BUN and/or CRE as well as serial CRP concentration measurements may be useful for predicting the prognosis of canine pancreatitis.

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Figures

Fig. 1.
Fig. 1.
Serial C-reactive protein (CRP) concentrations of survivors (S) and nonsurvivors (N) on days 1 to 5. *P<0.05.
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References

    1. Ceron J. J., Eckersall P. D., Martýnez-Subiela S.2005. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet. Clin. Pathol. 34: 85–99. doi: 10.1111/j.1939-165X.2005.tb00019.x - DOI - PubMed
    1. Cerón J. J., Martinez-Subiela S., Ohno K., Caldin M.2008. A seven-point plan for acute phase protein interpretation in companion animals. Vet. J. 177: 6–7. doi: 10.1016/j.tvjl.2007.12.001 - DOI - PubMed
    1. Eckersall P. D., Bell R.2010. Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet. J. 185: 23–27. doi: 10.1016/j.tvjl.2010.04.009 - DOI - PubMed
    1. Feldman B. F., Madewell B. R., O’Neill S.1981. Disseminated intravascular coagulation: antithrombin, plasminogen, and coagulation abnormalities in 41 dogs. J. Am. Vet. Med. Assoc. 179: 151–154. - PubMed
    1. Flatland B., Breickner L. C., Fry M. M.2014. Analytical performance of a dry chemistry analyzer designed for in-clinic use. Vet. Clin. Pathol. 43: 206–217. doi: 10.1111/vcp.12122 - DOI - PubMed