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Review
. 2016:2016:2124638.
doi: 10.1155/2016/2124638. Epub 2016 Sep 7.

Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective

Yingke Zhao  1 , Yue Liu  2 , Keji Chen  2
Affiliations
Review

Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective

Yingke Zhao et al. Oxid Med Cell Longev. 2016.

Abstract

Tetramethylpyrazine, a natural compound from Ligusticum wallichii (Chuan Xiong), has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystems, especially in cardiovascular, its pharmacological action, clinical application, and the structural modification have attracted broad attention. In this paper its mechanisms of action, the clinical status, and synthetic derivatives will be reviewed briefly.

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Figures

Figure 1
Figure 1
Illustration of Ligusticum wallichii (Chuan Xiong) plant (a) and chemical structure of ligustrazine (b).
Figure 2
Figure 2
Putative mechanisms underlying cardiovascular protective effects of TMP.
Figure 3
Figure 3
Primary intermediates of TMP.
See this image and copyright information in PMC

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