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Editorial
. 2016 Aug 12:3:37.
doi: 10.21037/sci.2016.08.03. eCollection 2016.

Pancreatic DCLK1 marks quiescent but oncogenic progenitors: a possible link to neuroendocrine tumors

Hironori Koga  1 , Yu Ikezono  1 , Takuji Torimura  1
Affiliations
Editorial

Pancreatic DCLK1 marks quiescent but oncogenic progenitors: a possible link to neuroendocrine tumors

Hironori Koga et al. Stem Cell Investig. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Protein expression levels of DCLK1 and SLUG in western blot. CM, human pancreatic neuroendocrine tumor cell line (kind gift from Professor Pozzilli); IMR (IMR-32), human neuroblastoma cell line; and B16, mouse melanoma cell line. 25 µg of cellular protein was subjected to the analysis. Antibodies for DCLK1 (rabbit monoclonal; clone EPR6085) and SLUG (rabbit polyclonal; No. ab27568) were obtained from abcam (Cambridge, UK).
See this image and copyright information in PMC

Comment in

  • Epithelial Dclk1+ cells are not neural crest derived.
    Westphalen CB, Middelhoff M, Quante M, Wang TC. Westphalen CB, et al. Stem Cell Investig. 2016 Oct 21;3:60. doi: 10.21037/sci.2016.10.02. eCollection 2016. Stem Cell Investig. 2016. PMID: 27868042 Free PMC article. No abstract available.

Comment on

  • Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.
    Westphalen CB, Takemoto Y, Tanaka T, Macchini M, Jiang Z, Renz BW, Chen X, Ormanns S, Nagar K, Tailor Y, May R, Cho Y, Asfaha S, Worthley DL, Hayakawa Y, Urbanska AM, Quante M, Reichert M, Broyde J, Subramaniam PS, Remotti H, Su GH, Rustgi AK, Friedman RA, Honig B, Califano A, Houchen CW, Olive KP, Wang TC. Westphalen CB, et al. Cell Stem Cell. 2016 Apr 7;18(4):441-55. doi: 10.1016/j.stem.2016.03.016. Cell Stem Cell. 2016. PMID: 27058937 Free PMC article.

References

    1. Shu T, Tseng HC, Sapir T, et al. Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression. Neuron 2006;49:25-39. 10.1016/j.neuron.2005.10.039 - DOI - PubMed
    1. Koizumi H, Higginbotham H, Poon T, et al. Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain. Nat Neurosci 2006;9:779-86. 10.1038/nn1704 - DOI - PubMed
    1. May R, Sureban SM, Lightfoot SA, et al. Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas. Am J Physiol Gastrointest Liver Physiol 2010;299:G303-10. 10.1152/ajpgi.00146.2010 - DOI - PMC - PubMed
    1. Nakanishi Y, Seno H, Fukuoka A, et al. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet 2013;45:98-103. 10.1038/ng.2481 - DOI - PubMed
    1. Bailey JM, Alsina J, Rasheed ZA, et al. DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. Gastroenterology 2014;146:245-56. 10.1053/j.gastro.2013.09.050 - DOI - PMC - PubMed

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