Aging vs. rejuvenation: reprogramming to iPSCs does not turn back the clock for somatic mitochondrial DNA mutations

Affiliations

¹ Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany;; Berlin Institute of Health (BIH), Berlin, Germany.
² Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany ;

Comment

Carmen Lorenz et al. Stem Cell Investig. 2016.

. 2016 Sep 1:3:43.

doi: 10.21037/sci.2016.08.09. eCollection 2016.

¹ Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany;; Berlin Institute of Health (BIH), Berlin, Germany.
² Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany ;

No abstract available

Conflict of interest statement

The authors have no conflicts of interest to declare.

Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs.
Kang E, Wang X, Tippner-Hedges R, Ma H, Folmes CD, Gutierrez NM, Lee Y, Van Dyken C, Ahmed R, Li Y, Koski A, Hayama T, Luo S, Harding CO, Amato P, Jensen J, Battaglia D, Lee D, Wu D, Terzic A, Wolf DP, Huang T, Mitalipov S. Kang E, et al. Cell Stem Cell. 2016 May 5;18(5):625-36. doi: 10.1016/j.stem.2016.02.005. Epub 2016 Apr 14. Cell Stem Cell. 2016. PMID: 27151456

1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76. 10.1016/j.cell.2006.07.024 - DOI - PubMed
1. Prigione A, Hossini AM, Lichtner B, et al. Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations. PLoS One 2011;6:e27352. 10.1371/journal.pone.0027352 - DOI - PMC - PubMed
1. Kang E, Wang X, Tippner-Hedges R, et al. Age-related accumulation of somatic mitochondrial DNA mutations in adult-derived human iPSCs. Cell Stem Cell 2016;18:625-36. 10.1016/j.stem.2016.02.005 - DOI - PubMed
1. Prigione A, Lichtner B, Kuhl H, et al. Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming. Stem Cells 2011;29:1338-48. - PubMed
1. Cortopassi GA, Shibata D, Soong NW, et al. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A 1992;89:7370-4. 10.1073/pnas.89.16.7370 - DOI - PMC - PubMed