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Comment
. 2016 Sep 27;316(12):1310-1.
doi: 10.1001/jama.2016.11212.

Blood Measurement of Carcinoembryonic Antigen Level for Detecting Recurrence of Colorectal Cancer

Brian D Nicholson  1 , Bethany Shinkins  2 , David Mant  1
Affiliations
Comment

Blood Measurement of Carcinoembryonic Antigen Level for Detecting Recurrence of Colorectal Cancer

Brian D Nicholson et al. JAMA. .

Abstract

Clinical question: What is the trade-off between sensitivity and specificity at specific carcinoembryonic antigen (CEA) thresholds for detecting recurrent colorectal cancer?

Bottom line: To detect colorectal cancer recurrence, the sensitivity of CEA ranges from 68% for a threshold of 10 µg/L to 82% for a threshold of 2.5 µg/L and the specificity ranges from 97% for a threshold of 10 µg/L to 80% for a threshold of 2.5 µg/L.

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  • Blood CEA levels for detecting recurrent colorectal cancer.
    Nicholson BD, Shinkins B, Pathiraja I, Roberts NW, James TJ, Mallett S, Perera R, Primrose JN, Mant D. Nicholson BD, et al. Cochrane Database Syst Rev. 2015 Dec 10;2015(12):CD011134. doi: 10.1002/14651858.CD011134.pub2. Cochrane Database Syst Rev. 2015. PMID: 26661580 Free PMC article.

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