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Comment
. 2016 Oct;16(10):1111-1112.
doi: 10.1016/S1473-3099(16)30340-1. Epub 2016 Sep 19.

Sertraline for HIV-associated cryptococcal meningitis - Authors' reply

Joshua Rhein  1 , Kirsten Nielsen  2 , David R Boulware  2 , David B Meya  3
Affiliations
Comment

Sertraline for HIV-associated cryptococcal meningitis - Authors' reply

Joshua Rhein et al. Lancet Infect Dis. 2016 Oct.
No abstract available

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Conflict of interest statement

We declare no competing interests.

Figures

Figure
Figure
luconazole plasma concentrations over 28 days when receiving fluconazole 800 mg/day for cryptococcal meningitis in Uganda. Fluconazole mean (±SD) levels increased from 30 (±14) μg/mL at 7 days to 41 (±14) μg/mL at 14 days to 52 (±19) μg/mL at 28 days, reflecting further accumulation due to a long half-life.
See this image and copyright information in PMC

Comment on

References

    1. Sudan A, Livermore J, Howard SJ, et al. Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints. Antimicrobial agents and chemotherapy. 2013;57(6):2793–800. - PMC - PubMed
    1. Rhein J, Morawski BM, Hullsiek KH, et al. Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study. The Lancet infectious diseases. 2016;16(7):809–18. - PMC - PubMed
    1. Smith KD, Achan B, Hullsiek KH, et al. Increased Antifungal Drug Resistance in Clinical Isolates of Cryptococcus neoformans in Uganda. Antimicrobial agents and chemotherapy. 2015;59(12):7197–204. - PMC - PubMed
    1. Zhai B, Wu C, Wang L, Sachs MS, Lin X. The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections. Antimicrobial agents and chemotherapy. 2012;56(7):3758–66. - PMC - PubMed
    1. Morawski BM, Boulware DR, Nalintya E, et al. Pre-ART Cryptococcal Antigen Titer Associated With Preemptive Fluconazole Failure. Conference on Retroviruses and Opportunistic Infections (CROI); Boston, MA. 2016.

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