Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Aug;67(4):534-6.

Increased sensitivity of the chemoattractant-induced chemiluminescence in eosinophils isolated from atopic individuals

L Koenderman  1 , P L Bruijnzeel
Affiliations

Increased sensitivity of the chemoattractant-induced chemiluminescence in eosinophils isolated from atopic individuals

L Koenderman et al. Immunology. 1989 Aug.

Abstract

Eosinophilia in peripheral blood is a common phenomenon associated with atopic condition. The present study illustrates the enhanced sensitivity of these eosinophils for formyl-methionyl-leucylphenylalanine (FMLP) and platelet-activating-factor (PAF) (measured as luminol-enhanced chemiluminescence) compared with eosinophils isolated from the peripheral blood of normal individuals. The PAF-induced chemiluminescence, which is peroxidase dependent and of extracellular origin, is inhibited by the PAF antagonist BN52021. The enhanced sensitivity of eosinophils isolated from atopic patients for FMLP and PAF might reflect a 'primed' state of these cells, relevant for the pathogenesis of atopic disease.

PubMed Disclaimer

References

    1. Blood. 1981 Dec;58(6):1175-81 - PubMed
    1. J Immunol. 1982 Oct;129(4):1589-93 - PubMed
    1. Int Arch Allergy Appl Immunol. 1983;72(4):336-46 - PubMed
    1. Biochim Biophys Acta. 1984 Jan 31;784(2-3):177-86 - PubMed
    1. FEBS Lett. 1984 Mar 12;168(1):23-8 - PubMed

Publication types

MeSH terms

Substances