Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul-Sep;31(3):149-55.
doi: 10.11138/fneur/2016.31.3.149.

New test of odor pleasantness in Parkinson's disease

Kristyna Pospichalova, Jan Vodicka, Ales Kopal

New test of odor pleasantness in Parkinson's disease

Kristyna Pospichalova et al. Funct Neurol. 2016 Jul-Sep.

Abstract

The New Test of Odor Pleasantness (NTOP) evaluates the hedonicity of olfactory stimulants. The aim of this study was to compare results of the NTOP, the Sniffin' Sticks test, and the Odorized Marker Test (OMT) in patients with Parkinson's disease (PD). The study sample comprised 30 PD patients (mean age 71±7.36 years) and the control group made up of 31 non-PD subjects (mean age 68±12.39 years). Sociodemographic data, medical history and tests of cognitive function were investigated. Olfaction was evaluated using the NTOP, Sniffin' Sticks test and OMT. The PD patients, compared with the control group, recorded significantly lower scores on all three tests: NTOP (p=0.00), Sniffin' Sticks (p=0.02), OMT (p=0.00). The NTOP was the test preferred by 55% of the subjects. This preference was more marked in the PD group. This study shows that the NTOP is a valuable method within the complex array of olfactory screening tools used in PD.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Boxplot of the results of the NTOP in the PD group (PDG, n=30) and control group (CG, n=30).
Figure 2
Figure 2
Boxplot of the results of the Sniffin’ Sticks (identification part) in the PD group (PDG, n=30) and control group (CG, n=30).
Figure 3
Figure 3
Boxplot of the results of the OMT (identification) in the PD group (PDG, n=30) and control group (CG, n=30).
See this image and copyright information in PMC

References

    1. Ansari KA, Johnson A. Olfactory function in patients with Parkinson’s disease. J Chronic Dis. 1975;28:493–497. - PubMed
    1. Bodis-Wollner I. The visual system in Parkinson’s disease. Res Publ Assoc Res Nerv Ment Dis. 1990;67:297–316. - PubMed
    1. Bohnen NI, Müller ML, Kotagal V, et al. Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson’s disease. Brain. 2010;133:1747–1754. - PMC - PubMed
    1. Bohnen NI, Gedela S, Herath P, et al. Selective hyposmia in Parkinson disease: association with hippocampal dopamine activity. Neurosci Lett. 2008;447:12–16. - PMC - PubMed
    1. Bossuyt PM, Reitsma JB, Bruns DE, et al. Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. BMJ. 2003;326:41–44. - PMC - PubMed

Publication types

LinkOut - more resources