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Editorial
. 2016 Nov 1;134(18):1369-1372.
doi: 10.1161/CIRCULATIONAHA.116.024520. Epub 2016 Sep 27.

Is Hypertension a Bone Marrow Disease?

Kim Ramil C Montaniel  1 , David G Harrison  2
Affiliations
Editorial

Is Hypertension a Bone Marrow Disease?

Kim Ramil C Montaniel et al. Circulation. .
No abstract available

Keywords: CXCR2; Editorials; hypertension; inflammation; oxidant stress.

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Conflict of interest statement

Disclosures: None.

Figures

Figure
Figure
Various factors common to the hypertensive milieu, including ang II, salt, catecholamines, chemokines and cytokines likely act on the bone marrow to mobilize monocytes and other inflammatory cells, some of which express the surface marker CXCR2. These cells enter the circulation and are attracted to peripheral sites of inflammation, guided by interactions with ligands such as CXCL1. These monocytes become activated and undergo transformation to inflammatory macrophages, dendritic cells and likely fibrocytes, leading to organ damage, dysfunction and fibrosis.
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References

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