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. 2016 Sep-Oct;10(5):1195-1202.e1.
doi: 10.1016/j.jacl.2015.12.027. Epub 2016 Jan 6.

Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification

Maryam Zaid  1 , Katsuyuki Miura  2 , Akira Fujiyoshi  3 , Robert D Abbott  4 , Takashi Hisamatsu  2 , Aya Kadota  2 , Hisatomi Arima  2 , Sayaka Kadowaki  3 , Sayuki Torii  3 , Naoko Miyagawa  3 , Sentaro Suzuki  3 , Naoyuki Takashima  3 , Takayoshi Ohkubo  5 , Akira Sekikawa  6 , Hiroshi Maegawa  7 , Minoru Horie  8 , Yasuyuki Nakamura  9 , Tomonori Okamura  10 , Hirotsugu Ueshima  2 ; SESSA Research Group
Collaborators, Affiliations

Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification

Maryam Zaid et al. J Clin Lipidol. 2016 Sep-Oct.

Abstract

Background: Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C).

Objectives: Whether LDL-P is associated with subclinical atherosclerosis, independent of LDL-C, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis.

Methods: We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40-79 years from 2006-2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC; >0 Agatston score) were examined.

Results: LDL-P was significantly positively associated with cIMT and maintained this association after adjustments for LDL-C and other lipid measures. Although these lipid measures were positively associated with cIMT, model adjustment for LDL-P removed any significant relationships. Higher LDL-P was associated with a significantly higher odds ratio of CAC and further adjustment for LDL-C did not affect this relationship. In contrast, the LDL-C association with CAC was no longer significant after adjustment for LDL-P. Other lipid measures attenuated associations of LDL-P with CAC. Likewise, associations of these measures with CAC were attenuated when model adjustments for LDL-P were made.

Conclusions: In a community-based sample of Japanese men, free of clinical CVD, LDL-P was a robust marker for subclinical atherosclerosis, independent of LDL-C and other lipid measures. Associations of LDL-C and other lipid measures with either cIMT or CAC were generally not independent of LDL-P.

Keywords: Carotid intima-media thickness (cIMT); Coronary artery calcification (CAC); Low-density lipoprotein cholesterol (LDL-C); Low-density lipoprotein particle (LDL-P); Subclinical atherosclerosis.

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Conflict of interest statement

None.

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