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Review
. 2016 Dec;9(12):887-894.
doi: 10.1158/1940-6207.CAPR-16-0124. Epub 2016 Sep 27.

Colorectal Cancer and Dysplasia in Inflammatory Bowel Disease: A Review of Disease Epidemiology, Pathophysiology, and Management

Parambir S Dulai  1 , William J Sandborn  1 , Samir Gupta  2   3   4
Affiliations
Review

Colorectal Cancer and Dysplasia in Inflammatory Bowel Disease: A Review of Disease Epidemiology, Pathophysiology, and Management

Parambir S Dulai et al. Cancer Prev Res (Phila). 2016 Dec.

Abstract

Crohn disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) characterized by recurrent episodes of mucosal inflammation. This chronic mucosal inflammation has several potential consequences, one of which is the occurrence of colitis-associated colorectal cancer. Over the past decade, our understanding of the epidemiology, pathophysiology, and overall approach to diagnosing and managing colitis-associated colorectal cancer has grown considerably. In the current review article, we outline these advancements and highlight areas in need of further research. Cancer Prev Res; 9(12); 887-94. ©2016 AACR.

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Figures

Figure 1
Figure 1
Key alterations within the colitis associated colorectal cancer dysplasia-carcinoma sequence
Figure 2
Figure 2
Clinical approach to endoscopic dysplasia surveillance and management
See this image and copyright information in PMC

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