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. 2016 Sep 13:7:1425.
doi: 10.3389/fmicb.2016.01425. eCollection 2016.

Wide Distribution of Genes for Tetrahydromethanopterin/Methanofuran-Linked C1 Transfer Reactions Argues for Their Presence in the Common Ancestor of Bacteria and Archaea

Ludmila Chistoserdova  1
Affiliations

Wide Distribution of Genes for Tetrahydromethanopterin/Methanofuran-Linked C1 Transfer Reactions Argues for Their Presence in the Common Ancestor of Bacteria and Archaea

Ludmila Chistoserdova. Front Microbiol. .
No abstract available

Keywords: C1 transfer; evolution; methanofuran; methanogenesis; methylotrophy; tetrahydromethanopterin.

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Figures

Figure 1
Figure 1
A universal tree of life reconstructed by Hug et al. (2016), adapted (with authors' permission) to highlight the points of this Opinion Article. Hug et al. used 16 concatenated ribosomal protein sequences from 3083 organisms representing major known lineages at the Phylum level, with the exception of Proteobacteria, which are represented at the Class level, as these are not monophyletic. 1011 of the genomes utilized, reconstructed from metagenomes, represent uncultivated phyla. Phyla (Classes) containing representatives encoding enzymes for the entire or a partial set of the H4MPT/MF-linked reactions (Chistoserdova, 2011) are denoted by red stars, and names are magnified. Note, that the top right area of the tree is represented entirely by organisms without cultivated representatives, possessing small genomes, with evidence of restricted metabolic capacities and suggesting symbiotic lifestyle (references in Hug et al., 2016). Genes for the H4MPT/MF-linked functions were likely lost from these lineages, along with other functions such as the complete tricarboxylic acid cycle, amino acid biosynthesis, etc. (Hug et al., 2016).
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