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Review
. 2016 Sep 29;9(1):99.
doi: 10.1186/s13045-016-0333-7.

Long non-coding RNAs in the regulation of myeloid cells

Xinyu Tian  1   2 , Jie Tian  2 , Xinyi Tang  1 , Jie Ma  2 , Shengjun Wang  3   4
Affiliations
Review

Long non-coding RNAs in the regulation of myeloid cells

Xinyu Tian et al. J Hematol Oncol. .

Abstract

Long non-coding RNAs (lncRNAs) have been attracting immense research interests. The relevance of lncRNAs in biological and physiological as well as in pathological processes has increased along with the understanding of their various regulatory mechanisms. Abundant studies have indicated that lncRNAs are involved in the differentiation, proliferation, activation, and initiation of apoptosis in different cell types. However, most studies about the regulating biology of lncRNAs are currently focused on cancer cells. This review is focused on the widely unexplored role of lncRNAs in the cell fate of myeloid cells. In this review, we summarize recent studies that have confirmed lncRNAs to be essential in the development of myeloid cells under normal and pathological conditions.

Keywords: Cell development; Erythrocytes and megakaryocytes; Granulocytes; Long non-coding RNAs; Monocytes and macrophages.

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Figures

Fig. 1
Fig. 1
The regulatory mechanisms of lncRNAs located in nucleus and cytoplasm. a RNP component. b Epigenetic regulation. c TF docay. d Modulation of translation, splicing, and degradation. e MicroRNA sponge. f Regulating the activation of molecular
See this image and copyright information in PMC

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