Nucleosome mapping in plasma DNA predicts cancer gene expression
- PMID: 27681289
- DOI: 10.1038/ng.3686
Nucleosome mapping in plasma DNA predicts cancer gene expression
Abstract
A new study demonstrates that genomic sequencing coverage of plasma DNA fragments around transcription start sites reflects the expression levels of genes in corresponding tumors. This approach may enable noninvasive monitoring of treatment-induced changes in gene expression for patients with cancer.
Comment on
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Inferring expressed genes by whole-genome sequencing of plasma DNA.Nat Genet. 2016 Oct;48(10):1273-8. doi: 10.1038/ng.3648. Epub 2016 Aug 29. Nat Genet. 2016. PMID: 27571261
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