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Case Reports
. 2016 Nov 10;375(19):1907-1909.
doi: 10.1056/NEJMc1610613. Epub 2016 Sep 28.

Fatal Zika Virus Infection with Secondary Nonsexual Transmission

Sankar Swaminathan  1   2 , Robert Schlaberg  1 , Julia Lewis  1 , Kimberly E Hanson  1 , Marc R Couturier  1
Affiliations
Case Reports

Fatal Zika Virus Infection with Secondary Nonsexual Transmission

Sankar Swaminathan et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Identification and Characterization of ZIKV on RNA Sequencing of Serum from Patient 1
Panel A shows that 1.5% of complementary DNA sequencing reads were of viral origin (pie chart). Partial external arcs indicate the proportion of viral reads that could be fully classified and human reads derived from messenger RNA transcripts. Viral sequences were identified as Zika virus (ZIKV) by means of Taxonomer software. Classification results for viral sequences are shown as a sunburst graph, in which the relative abundance of read-level classification is shown by the size of a given slice, with the highest taxonomic rank in the center and species-level classification in the periphery. The abbreviation ssRNA denotes single-stranded RNA. Panel B shows synonymous and nonsynonymous changes in the ZIKV isolate genome, as compared with its closest taxonomic relatives. Complete sequence information is available at GenBank (accession number, KX827268).
See this image and copyright information in PMC

Comment in

  • Zika virus: are we going too far?
    Vouga M, Musso D, Schaub B, Panchaud A, Baud D. Vouga M, et al. Lancet. 2017 Jan 14;389(10065):151. doi: 10.1016/S0140-6736(17)30013-2. Epub 2017 Jan 13. Lancet. 2017. PMID: 28102134 No abstract available.

References

    1. Pan American Health Organization, World Health Organization. Cumulative Zika suspected and confirmed cases reported by countries and territories in the Americas, 2015–2016. ( http://ais.paho.org/phip/viz/ed_zika_cases.asp)
    1. Duffy MR, Chen T-H, Hancock WT, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360:2536–2543. - PubMed
    1. Flygare S, Simmon K, Miller C, et al. Taxonomer: an interactive metagenomics analysis portal for universal pathogen detection and host mRNA expression profiling. Genome Biol. 2016;17:111. - PMC - PubMed
    1. Kraemer MU, Sinka ME, Duda KA, et al. The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus. Elife. 2015;4:e08347. - PMC - PubMed
    1. Chen LH, Wilson ME. Transmission of dengue virus without a mosquito vector: nosocomial mucocutaneous transmission and other routes of transmission. Clin Infect Dis. 2004;39(6):e56–e60. - PubMed