Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate

Adnan Amin¹, Emmy Tuenter², Paul Cos³, Louis Maes⁴, Vassiliki Exarchou⁵, Sandra Apers⁶, Luc Pieters⁷

Affiliations

¹ Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. dani_amin79@yahoo.com.
² Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. emmy.tuenter@uatwerpen.be.
³ Laboratory of Parasitology, Microbiology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. paul.cos@uantwerpen.be.
⁴ Laboratory of Parasitology, Microbiology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. louis.maes@uantwerpen.be.
⁵ Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. vasiliki.exarchou@uantwerpen.be.
⁶ Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. sandra.apers@uantwerpen.be.
⁷ Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. luc.pieters@uantwerpen.be.

PMID: 27681714
PMCID: PMC6274357
DOI: 10.3390/molecules21101287

Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate

Adnan Amin et al. Molecules. 2016.

. 2016 Sep 26;21(10):1287.

doi: 10.3390/molecules21101287.

Authors

Adnan Amin¹, Emmy Tuenter², Paul Cos³, Louis Maes⁴, Vassiliki Exarchou⁵, Sandra Apers⁶, Luc Pieters⁷

Affiliations

¹ Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. dani_amin79@yahoo.com.
² Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. emmy.tuenter@uatwerpen.be.
³ Laboratory of Parasitology, Microbiology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. paul.cos@uantwerpen.be.
⁴ Laboratory of Parasitology, Microbiology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. louis.maes@uantwerpen.be.
⁵ Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. vasiliki.exarchou@uantwerpen.be.
⁶ Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. sandra.apers@uantwerpen.be.
⁷ Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. luc.pieters@uantwerpen.be.

PMID: 27681714
PMCID: PMC6274357
DOI: 10.3390/molecules21101287

Abstract

The exudate of Ferula narthex Boiss. (Apiaceae) is widely used in the Indian subcontinent as a spice and because of its health effects. Six sesquiterpene coumarins have been isolated from this exudate: feselol, ligupersin A, asacoumarin A, 8'-O-acetyl-asacoumarin A, 10'R-karatavacinol and 10'R-acetyl-karatavacinol. Based on its use in infectious and diabetic conditions, the isolated constituents were evaluated for antimicrobial and antiglycation activities. Some compounds showed activity against protozoal parasites, asacoumarin A being the most active one against Plasmodium falciparum K1 (IC₅₀ 1.3 μM). With regard to antiglycation activity, in the BSA-glucose test, ligupersin A displayed the highest activity (IC₅₀ 0.41 mM), being more active than the positive control aminiguanidine (IC₅₀ 1.75 mM). In the BSA-MGO assay, the highest activity was shown by 8'-O-acetyl-asacoumarin A (IC₅₀ 1.03 mM), being less active than aminoguanidine (IC₅₀ 0.15 mM). Hence, the antiglycation activity of the isolated constituents was due to both oxidative and non-oxidative modes of inhibition.

Keywords: Apiaceae; Ferula narthex; antiglycation activity; antiprotozoal activity; exudate; sesquiterpene coumarins.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Structures of isolated constituents (1–6).

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Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate

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Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate

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Conflict of interest statement

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