. 2016 Sep 26;17(10):1616.

doi: 10.3390/ijms17101616.

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Yu-Jie Zhang¹, Tong Zhou², Fang Wang³, Yue Zhou⁴, Ya Li⁵, Jiao-Jiao Zhang⁶, Jie Zheng⁷, Dong-Ping Xu⁸, Hua-Bin Li^{9

10}

Affiliations

¹ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhyujie3@mail2.sysu.edu.cn.
² Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhout43@mail2.sysu.edu.cn.
³ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. missingfeng@yeah.net.
⁴ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhouyue3@mail2.sysu.edu.cn.
⁵ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. liya28@mail2.sysu.edu.cn.
⁶ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhangjj46@mail2.sysu.edu.cn.
⁷ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhengj37@mail2.sysu.edu.cn.
⁸ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. xudp@mail2.sysu.edu.cn.
⁹ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.
¹⁰ South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-sen University, Guangzhou 510006, China. lihuabin@mail.sysu.edu.cn.

PMID: 27681723
PMCID: PMC5085649
DOI: 10.3390/ijms17101616

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Yu-Jie Zhang et al. Int J Mol Sci. 2016.

. 2016 Sep 26;17(10):1616.

doi: 10.3390/ijms17101616.

Authors

Yu-Jie Zhang¹, Tong Zhou², Fang Wang³, Yue Zhou⁴, Ya Li⁵, Jiao-Jiao Zhang⁶, Jie Zheng⁷, Dong-Ping Xu⁸, Hua-Bin Li^{9

10}

Affiliations

¹ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhyujie3@mail2.sysu.edu.cn.
² Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhout43@mail2.sysu.edu.cn.
³ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. missingfeng@yeah.net.
⁴ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhouyue3@mail2.sysu.edu.cn.
⁵ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. liya28@mail2.sysu.edu.cn.
⁶ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhangjj46@mail2.sysu.edu.cn.
⁷ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhengj37@mail2.sysu.edu.cn.
⁸ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. xudp@mail2.sysu.edu.cn.
⁹ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.
¹⁰ South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-sen University, Guangzhou 510006, China. lihuabin@mail.sysu.edu.cn.

PMID: 27681723
PMCID: PMC5085649
DOI: 10.3390/ijms17101616

Abstract

Previous studies have shown that fruits have different effects on alcohol metabolism and alcohol-induced liver injury. The present work selected three fruits and aimed at studying the effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on alcohol-induced liver injury in mice. The animals were treated daily with alcohol and fruit juices for fifteen days. Chronic treatment with alcohol increased the levels of aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL), triglyceride (TG), malondialdehyde (MDA), and decreased total protein (TP). Histopathological evaluation also showed that ethanol induced extensive fat droplets in hepatocyte cytoplasm. Syzygium samarangense and Passiflora edulis normalized various biochemical parameters. Solanum muricatum increased the level of ALT and induced infiltration of inflammatory cells in the liver. These results strongly suggest that treatment with Syzygium samarangense and Passiflora edulis could protect liver from the injury of alcohol, while Solanum muricatum could aggravate the damage.

Keywords: Passiflora edulis; Solanum muricatum; Syzygium samarangense; alcohol; liver injury.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Effects of *Syzygium samarangense*, *Passiflora edulis* and *Solanum muricatum* on the levels of aspartate transaminase (AST) (a); alanine transaminase (ALT) (b); and alkaline phosphatase (ALP) (c) in serum. ^# indicates that there is a significant (p < 0.05) difference between the model group and the control group. * indicates that there is a significant (p < 0.05) difference between the treatment group and the model group. SS + AL: *Syzygium samarangense* + alcohol; PE + AL: *Passiflora edulis* + alcohol; SM + AL: *Solanum muricatum* + alcohol.

**Figure 2**
Effects of *Syzygium samarangense*, *Passiflora edulis* and *Solanum muricatum* on the levels of serum total bilirubin (TBIL) (a); triglyceride (TG) (b); total protein (TP) (c); and hepatic TG (d). ^# indicates that there is a significant (p < 0.05) difference between the model group and the control group. * indicates that there is a significant (p < 0.05) difference between the treatment group and the model group. SS + AL: *Syzygium samarangense* + alcohol; PE + AL: *Passiflora edulis* + alcohol; SM + AL: *Solanum muricatum* + alcohol.

**Figure 3**
Effects of *Syzygium samarangense*, *Passiflora edulis* and *Solanum muricatum* on the contents of MDA (a); and GSH (b) in the liver. ^# indicates that there is a significant (p < 0.05) difference between the model group and the control group. * indicates that there is a significant (p < 0.05) difference between the treatment group and the model group. SS + AL: *Syzygium samarangense* + alcohol; PE + AL: *Passiflora edulis* + alcohol; SM + AL: *Solanum muricatum* + alcohol.

**Figure 4**
Effects of *Syzygium samarangense*, *Passiflora edulis* and *Solanum muricatum* on the levels of hepatic SOD (a); and CAT (b). ^# indicates that there is a significant (p < 0.05) difference between the model group and the control group. * indicates that there is a significant (p < 0.05) difference between the treatment group and the model group. SS + AL: *Syzygium samarangense* + alcohol; PE + AL: *Passiflora edulis* + alcohol; SM + AL: *Solanum muricatum* + alcohol.

**Figure 5**
Representative liver sections stained with hematoxylin-eosin (H&E). Arrow indicates infiltration of inflammatory cells, which mainly occurred in the *Solanum muricatum* group. (a) histopathological image of liver in the control group; (b) histopathological image of liver in the model group; (c) histopathological image of the liver in the alcohol + *Syzygium samarangense* group; (d) histopathological image of the liver in the alcohol + *Passiflora edulis* group; (e) histopathology image of the liver in the alcohol + *Solanum muricatum* group.

**Figure 6**
Effects of fruit juices alone (without alcohol) on the levels of ALT (a), AST (a) and TBIL (b) in serum as well as TG (c) and MDA (d) in the liver. SS: *Syzygium samarangense*; PE: *Passiflora edulis*; SM: *Solanum muricatum*.

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The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

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The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

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Abstract

Conflict of interest statement

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