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. 2016 Oct 24;55(44):13854-13858.
doi: 10.1002/anie.201607493. Epub 2016 Sep 29.

Highly Diastereo- and Enantioselective Cu-Catalyzed Borylative Coupling of 1,3-Dienes and Aldimines

Liyin Jiang  1   2 , Peng Cao  3   4 , Min Wang  1   2 , Bin Chen  5 , Bing Wang  1   2 , Jian Liao  6   7   8
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Highly Diastereo- and Enantioselective Cu-Catalyzed Borylative Coupling of 1,3-Dienes and Aldimines

Liyin Jiang et al. Angew Chem Int Ed Engl. .

Abstract

A Cu-catalyzed diastereo- and enantioselective borylative coupling reaction of 1,3-dienes with imines was realized. Branched homoallylic amines are readily prepared in a syn-selective manner with high regio-, diastereo- and enantioselectivity. Moreover, these three-component coupling reactions feature good functional-group compatibility and easy access to the substrates and catalyst.

Keywords: 1,3-dienes; asymmetric catalysis; borylative coupling; copper; imines.

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