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. 2009 Apr 20;20(1):21-7.
eCollection 2009 Apr.

3. Podocyte Injury in Glomerular Diseases

Mirjana Sabljar Matovinović

3. Podocyte Injury in Glomerular Diseases

Mirjana Sabljar Matovinović. EJIFCC. .
No abstract available

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Figures

Figure 3.1.
Figure 3.1.
The spectrum of podocyte diseases. (6).
Figure 3.2.
Figure 3.2.
Glomerular filtration barrier. 1. Fenestrated endothelium; 2. glomerular basement membrane; 3 podocyte foot processes and slit diaphragm
Figure 3.3.
Figure 3.3.
The three boxes (1-3) in the right half define the three domains of the foot processes: 1. junctional - slit diaphragm complex; 2. basal domain and GBM; 3. apical plasma domain with glycocalyx. Interference with any of these three domains can cause foot process effacement and nephrotic syndrome.
Figure 3.4.
Figure 3.4.
The slit diaphragm of podocytes is a specialized cell junction with signaling properties. It connects interdigitating foot processes serving as an essential part of the glomerular filtration barrier. Slit diaphargm proteins (nephrin and neph1) recruit cytoplasmatic adaptor proteins to initiate signal transduction.
Figure 3.5.
Figure 3.5.
Foot processes effacement. a) normal; b) foot processes effacement
See this image and copyright information in PMC

References

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