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. 2016 Dec 15;214(12):1817-1821.
doi: 10.1093/infdis/jiw459. Epub 2016 Sep 28.

Cigarette Smoking and Inflammation, Monocyte Activation, and Coagulation in HIV-Infected Individuals Receiving Antiretroviral Therapy, Compared With Uninfected Individuals

Katherine W Kooij  1   2 , Ferdinand W N M Wit  1   3   4   2   5 , Thijs Booiman  1   6   2 , Marc van der Valk  3   4 , Maarten F Schim van der Loeff  3   4   7 , Neeltje A Kootstra  6 , Peter Reiss  1   3   4   2   5 ; AGEhIV Cohort Study Group
Collaborators, Affiliations

Cigarette Smoking and Inflammation, Monocyte Activation, and Coagulation in HIV-Infected Individuals Receiving Antiretroviral Therapy, Compared With Uninfected Individuals

Katherine W Kooij et al. J Infect Dis. .

Abstract

Smoking may affect cardiovascular disease risk more strongly in human immunodeficiency virus (HIV)-infected individuals than HIV-uninfected individuals. We hypothesized that an interaction at the level of the immune system may contribute to this increased risk. We assessed soluble markers of inflammation (high-sensitivity C-reactive protein [hsCRP]), immune activation (soluble [s]CD14 and sCD163), and coagulation (D-dimer) in HIV-infected and uninfected never, former, and current smokers. Smoking was independently associated with higher hsCRP levels and lower sCD163 levels and was borderline significantly associated with higher sCD14 and D-dimer levels. We found no evidence of a differential effect of smoking in HIV-infected individuals as compared to uninfected individuals.

Keywords: HIV infection; coagulation; inflammation; monocyte activation; smoking.

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