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Randomized Controlled Trial
. 2017 Jan;37(1):61-66.
doi: 10.1038/jp.2016.159. Epub 2016 Sep 29.

Prospective economic evaluation alongside the non-invasive ventilation trial

M E Mowitz  1 , J A F Zupancic  2   3   4 , D Millar  5 , H Kirpalani  6   7 , J S Gaulton  4 , R S Roberts  6   7 , W Mao  3 , D Dukhovny  3   8
Affiliations
Randomized Controlled Trial

Prospective economic evaluation alongside the non-invasive ventilation trial

M E Mowitz et al. J Perinatol. 2017 Jan.

Abstract

Objective: To determine the cost-effectiveness of nasal continuous positive pressure (nCPAP) compared with nasal intermittent positive pressure ventilation (NIPPV) in the context of the reported randomized clinical trial.

Study design: Using patient-level data from the clinical trial, we undertook a prospectively planned economic evaluation. We measured costs, from a third-party payer perspective in all patients, and from a societal perspective in a subgroup with a time horizon through the earlier of discharge, death or 44 weeks post-menstrual age.

Results: From the third-party payer perspective, the mean cost of hospitalization per infant was statistically similar, $143 745 in the NIPPV group compared to $140 403 in the nCPAP group. Cost-effectiveness evaluation revealed a 61% probability that NIPPV is more expensive and less effective than nCPAP. Similar results were found in subgroup analysis from a societal perspective.

Conclusion: In addition to being clinically equivalent, economic evaluation confirms that NIPPV, as employed in this trial, is also not economically favorable.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
Figure 1 displays the incremental cost-effectiveness plot for the primary analysis. The difference in effects is seen on the x axis, whereas the difference in costs is seen on the y axis. Each dot represents one boot-strapping replication.
Figure 2.
Figure 2.
Figure 2 displays the cost-effectiveness acceptability curve. The x axis shows the willingness-to pay in US dollars, whereas the y axis shows the probability that the iCER lies within the threshold.
See this image and copyright information in PMC

References

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