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. 2017 Jan 2:227:49-56.
doi: 10.1016/j.virusres.2016.09.013. Epub 2016 Sep 26.

Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper

Seung Mok Ryu  1 , Jaeyoung Kwon  2 , Young Hye Seo  1 , Eun Gyeong Song  3 , Seong Su Hong  4 , Beom Seok Kim  1 , Jin Sung Hong  5 , Ki Hyun Ryu  6 , Dongho Lee  7
Affiliations

Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper

Seung Mok Ryu et al. Virus Res. .

Abstract

A green fluorescent protein (GFP)-tagged pepper mottle virus (PepMoV) based leaf-disc method and systemic host method were developed to identify antiviral agents. Preliminary experiments using a PepMoV-GFP based leaf-disc method led to the isolation of five quassinoids, including brusatol (1), bruceantin (2), brucein A (3), bruceantinol (4), and brucein B (5), from the CH3OH extract of Brucea javanica. All isolated compounds exhibited inactivation effects in systemic host plants, and compounds 3 and 4 were potent, with a minimum inhibitory concentration of 10μM. Furthermore, compound 3 was found to have a protective effect at the tested concentration of 40μM.

Keywords: Antiviral agent; Brucea javanica; Capsicum annuum; Green fluorescent protein; Pepper mottle virus; Quassinoid.

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