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Review
. 2017 Feb;16(1):4-16.
doi: 10.1111/acel.12538. Epub 2016 Sep 29.

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

Aneesa Ansari  1 , Md Shahedur Rahman  1 , Subbroto K Saha  2 , Forhad K Saikot  1 , Akash Deep  3 , Ki-Hyun Kim  4
Affiliations
Review

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

Aneesa Ansari et al. Aging Cell. 2017 Feb.

Abstract

In mammals, seven members of the sirtuin protein family known as class III histone deacetylase have been identified for their characteristic features. These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involvement in diseases. Among the sirtuin members, SIRT3 has received much attention for its role in cancer genetics, aging, neurodegenerative disease, and stress resistance. SIRT3 controls energy demand during stress conditions such as fasting and exercise as well as metabolism through the deacetylation and acetylation of mitochondrial enzymes. SIRT3 is well known for its ability to eliminate reactive oxygen species and to prevent the development of cancerous cells or apoptosis. This review article provides a comprehensive review on numerous (noteworthy) molecular functions of SIRT3 and its effect on cancer cells and various diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease.

Keywords: SIRT3; Silent Information Regulator 2; aging; cancer; sirtuin.

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Figures

Figure 1
Figure 1
Molecular functions of SIRT3.
Figure 2
Figure 2
SIRT3 protect neurons during cellular stress.
Figure 3
Figure 3
SIRT3‐mediated protection of cardiac and skeletal muscle during hypertrophy and fasting, respectively.
Figure 4
Figure 4
SIRT3 regulates aging by interacting with FOXO.
Figure 5
Figure 5
SIRT3 has both oncogenic and tumor suppressive activities.
Figure 6
Figure 6
Function of SIRT3 in lung cancer.
See this image and copyright information in PMC

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